Objective To investigate the effect of interfering HSPC 238 on cervical cancer Hela cells tumorigenesis in nude mice . Methods PLL3 .7-PSMA7 interfering vectors were stably transfected into Hela cells .Then the cells were subcutaneously inocula-ted into the anterior limb armpit of the BALB/c nude mice .The appearance time and volume change of tumor were observed . Results Compared with control group ,the nude mice tumor of the transfected PLL3 .7-HSPC238 interfering vector group grew more fast and the volume was bigger ,the difference was statistically significant .Conclusion Interfering HSPC238 has a promoting effect on cervical cancer Hela cell tumorigenesis in nude mice .%目的 观察干扰HSPC238对宫颈癌Hela细胞裸鼠成瘤的影响.方法 将PLL3.7-HSPC238干扰载体稳定转染Hela细胞,然后将细胞接种到BALB/c裸鼠前肢腋部皮下,观察肿瘤出现时间及体积变化.结果 转染了PLL3.7-HSPC238干扰载体组的裸鼠肿瘤较对照组生长快,肿瘤的体积明显大于对照组,差异有统计学意义(P<0.05).结论 干扰HSPC238对宫颈癌H ela细胞裸鼠成瘤具有促进作用.
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