Objective To explore the change of serum SCC andβ2 microglobulin(β2-MG) in the patients with chronic kidney dis-ease(CKD) and their correlation .Methods A total of 96 CKD patients were included into the experimental group and contempora-neous 106 persons undergoing physical examination were included into the control group ;the CKD patients were divided into the stage 1 group(n=21) ,stage 2 group(n=15) ,stage 3 group(n=25) and stage 4~5 group(n=35) by GFR .The levels of serum SCC ,β2-MG and creatinine in the experimental and control groups were detected ;the changes of serum SCC and β2-MG were ana-lyzed and the correlation between them in CKD patients were analyzed .Results The levels of serum SCC ,β2-MG and creatinine in the experimental group were significantly higher than those in the control group and the difference had statistical significance (P<0 .05);the three indicator′s values were significantly increased with the disease condition aggravation (P<0 .05);the positive corre-lation was demonstrated between serum SCC and β2-MG(r=0 .719 ,P<0 .05) and between serum SCC and creatinine(r=0 .756 , P<0 .05);the areas under the curve of serum SCC ,β2-MG and creatinine for diagnosing CKD were 0 .921 ,0 .955 and 0 .949 respec-tively .Conclusion The levels of serum SCC ,β2-MG and creatinine in CKD patients are increased significantly ,which have a greater diagnostic value for CKD ,moreover the serum SCC shows stronger correlations with β2-MG and creatinine .%目的 探讨慢性肾脏病(CKD)患者血清鳞状细胞癌抗原(SCC)与β2微球蛋白(β2-MG)的变化及指标之间的相关性.方法 CKD患者96例纳入试验组,同期106例健康体检者纳入对照组;按照肾小球滤过率将CKD患者分为CKD 1期21例,CKD 2期15例,CKD 3期25例,CKD 4~5期35例;检测试验组和对照组研究对象的血清SCC,β2-MG和肌酐水平,分析CKD患者血清SCC与β2-MG的变化及其相关性.结果 试验组中CKD患者血清SCC、β2-MG和肌酐水平显著高于对照组,差异均有统计学意义(P<0.05),且随着病情的加重3个指标都明显升高(P<0.05);血清SCC水平与β2-MG呈正相关(r=0.719,P<0.05),与肌酐也呈正相关(r=0.756,P<0.05);血清SCC、β2-MG和肌酐3个指标诊断CKD的曲线下面积分别为0.921、0.955、0.949.结论 CKD患者血清SCC、β2-MG和肌酐水平均显著升高,对CKD有较大的诊断价值,而且血清SCC与β2-MG、肌酐均具有较强的相关性.
展开▼
