Objective To study the serum Wnt2 level in the patients with various tumors(breast cancer ,ovari‐an cancer ,cervical cancer ,lung cancer ,liver cancer)for evaluating its clinical application value in tumor .Methods The serum Wnt2 level in the patients with various tumors was detected by enzyme linked immunosorbent assay(ELISA) . Results Compared with the healthy group ,the serum Wnt2 level in breast cancer ,ovarian cancer and cervical cancer was significantly increased(P<0 .05) ,the serum Wnt2 level in the patients with hepatocellular carcinoma was signifi‐cantly decreased ,while which in the patients with lung cancer had no significant change .Conclusion The serum Wnt2 level is not consistent and may play different role in different types of tumor .%目的：检测多种肿瘤患者（乳腺癌、卵巢癌、宫颈癌、肺癌、肝癌）血清中Wnt2水平，评价Wnt2在肿瘤中的临床应用价值。方法采用酶联免疫吸附试验（ELISA）检测多种肿瘤患者血清中Wnt2水平。结果与健康者比较，乳腺癌、卵巢癌、宫颈癌患者血清中Wnt2水平均明显升高（均P＜0．05），肝癌患者血清中Wnt2水平明显降低（P＜0．05），肺癌患者血清中Wnt2水平无明显变化（P＞0．05）。结论Wnt2在不同类别的肿瘤中水平不一致，可能在不同类别的肿瘤中起不同的作用。
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