目的：探讨大剂量分割放疗和常规分割放疗在乳腺癌根治术中的临床疗效，为临床选择乳腺癌根治术后患者放疗选择更好的方式。方法：回顾性分析2008年9月-2010年9月期间本院行放疗的210例乳腺癌根治术患者，其中行常规分割放疗患者110例为对照组，行大剂量分割放疗100例为观察组，比较两组患者在不同放疗方案下的1、3及5年总生存率，治疗后局部复发率、远处转移率以及急性不良反应发生率。结果：对照组1、3、5年生存率分别为95.45%、87.27%、79.09%，观察组分别为97.00%、92.00%、83.00%，两组比较差异无统计学意义（P>0.05）。对照组的局部复发率8.18%，观察组为7.00%，两组比较差异无统计学意义（P>0.05）。对照的远处转移率为3.64%，观察组为3.00%（3/100），两组比较差异无统计学意义（P>0.05）。急性不良反应以放射性肺炎、放射性皮肤反应为主，其中对照组不良反应发生率为33.64%，观察组不良反应发生率为32.00%，两组比较差异无统计学意义（P>0.05）。结论：对于乳腺癌根治术后行放疗的患者，大剂量分割疗法在保证疗效、生存率同时大幅缩短了患者的疗程时间，减轻了患者的负担和经济压力。%Objective:To study the clinical effect of large dose and conventional dose of fractionated radiotherapy in the radical mastectomy and choose a better therapy for patients with breast cancer.Method:The data about 210 patients of receiving the radical mastectomy and fractionated radiotherapy from September 2008 to September 2010 in our hospital was retrospectively analyzed.The subjects were divided into control group of 110 cases and observation group of 100 cases.The control group was given the conventional dose of fractionated radiotherapy,the observation group was given the large dose of fractionated radiotherapy.After 1,3 and 5 years treatment,the overall survival rates of two groups were compared, the local recurrence rate, distant metastasis rate and the incidence rate of acute adverse reactions of two groups were observed.Result:After 1,3 and 5 years treatment,the overall survival rate in control group were respectively 95.45%,87.27% and 79.09%;the overall survival rate in observation group were respectively 97.00%,92.00% and 83.00%,the differences were no statistically significant(P>0.05).The local recurrence rate for control group and observation group was respectively 8.18% and 7.00%,the difference was statistically significant(P>0.05).The distant metastasis rate for control group and observation group was respectively 3.64% and 3.00%,the difference was no statistically significant(P>0.05).The major acute adverse reactions were radiation pneumonitis and radition skin reaction, the adverse event rate for control group and observation group was respectively 33.64% and 32.00%,the difference was no statistically significant(P>0.05).Conclusion:After the radical mastectomy, the large dose of fractionated radiotherapy can guarantee the curative effect and survival rate,shorten the treatment courses,reduce the patients’ burden and economic pressure.
展开▼
