Objective:To investigate the value of combined detection of thrombospondin-1(TSP-1) and D-dimer in the differential diagnosis of acute coronary syndrome(ACS) and acute aortic dissection(AAD) patients.Method:Serum of 120 patients with ACS,120 patients with AAD and 60 healthy people were collected. The serum levels of TSP-1 and D-dimer in three groups were detected respectively,and the results were analyzed. Result:The levels of TSP-1 and D-dimer were higher in ACS group and AAD group than those of normal control group(P<0.05),and TSP-1 was more remarkably in ACS group while D-dimer was more remarkably in AAD group.Conclusion:Combined detection of TSP-1 and D-dimer can help to identify ACS and AAD.%目的：探讨凝血酶敏感蛋白-1（thrombospondin-1，TSP-1）和D-二聚体（D-dimer）联合检测对急性冠脉综合征（acute coronary syndrome，ACS）和急性主动脉夹层（acute aortic dissection，AAD）患者的鉴别诊断价值。方法：收集ACS组患者120例、AAD组患者120例和正常对照组60例，取血清，分别检测TSP-1和D-dimer在三组中的血清水平，并对结果进行分析。结果：TSP-1和D-dimer在ACS组、AAD组浓度均高于正常对照组（P<0.05），而TSP-1在ACS组升高更明显，D-dimer在AAD组升高更明显。结论：TSP-1和D-dimer联合检测可以协助ACS和AAD这两种疾病的鉴别诊断。
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