Objective:To observe the effect of insulin pump intensive therapy inβcell function of different body mass index in patients with type 2 diabetes,insulin resistance and long-term remission. Method:Patients with type 2 diabetes in our hospital were divided into two groups according to body mass index:the obesity group and normal group. All patients were treated with insulin pump intensive treatment. 2 weeks before and after treatment, 18 months after treatment,theβcell function and insulin resistance were taken for analysis. Result:The HOMA-β,HOMA-IR in the obesity group before and after treatment in patients were significantly higher than those in the normal group(P<0.05).After 2 weeks of treatment,two groups of patients with HOMA-β,HOMA-IR and efficacy compared to baseline values were significantly decreased(P<0.05);follow-up results after 18 months, patients in the two group,HOMA-βHOMA-IR and efficacy compared to baseline values were significantly decreased(P<0.05).Conclusion:Insulin pump therapy in the treatment of different body mass index in patients has the improving function with newly diagnosed type 2 diabetes isletβcell function, insulin resistance,also has the effect of long-term remission.% 目的：观察胰岛素泵强化治疗对不同体重指数初诊2型糖尿病胰岛β细胞功能、胰岛素抵抗的影响。方法：将本院收诊的2型糖尿病患者按体重指数分成两组，肥胖组和正常组。所有患者均采用胰岛素泵进行强化治疗，分别于治疗前、治疗2周后、治疗18个月后对胰岛β细胞功能、胰岛素抵抗进行分析。结果：肥胖组患者治疗前后HOMA-β、HOMA-IR均显著高于正常组（P<0.05）；治疗2周后，两组患者的HOMA-β、HOMA-IR与疗效基线值相比均显著下降（P<0.05）；18个月后随访结果发现，两组患者的HOMA-β、HOMA-IR与疗效基线值相比仍显著下降（P<0.05）。结论：胰岛素泵强化治疗对不同体重指数初诊2型糖尿病胰岛β细胞功能、胰岛素抵抗均有改善作用，而且具有长期缓解作用。
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