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首页> 外文期刊>Therapeutic advances in endocrinology and metabolism. >An investigation of the associations among sleep duration and quality, body mass index and insulin resistance in newly diagnosed type 2 diabetes mellitus patients
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An investigation of the associations among sleep duration and quality, body mass index and insulin resistance in newly diagnosed type 2 diabetes mellitus patients

机译：初诊2型糖尿病患者睡眠时间与质量，体重指数和胰岛素抵抗之间的关系研究

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To examine direct and indirect associations of sleep duration and quality with insulin resistance, considering body mass index (BMI) as a potential mediator in newly diagnosed type 2 diabetes mellitus patients. Cross-sectional data from patients enrolled in the Early Activity in Diabetes study. We studied 522 newly diagnosed type 2 diabetes mellitus patients, 65.9% male, mean age 63.5 ± 10.1 years. Of the total sample 53% had a BMI of ?30 kg/m2. Participants completed a 7-day sleep diary and sleep questionnaire. Average sleep duration (minutes), average nap duration (minutes) and average number of night awakenings were derived. Objective measures of height and body weight were obtained for the BMI calculation (kg/m2). Insulin resistance was obtained using the homeostatic model assessment – insulin resistance (HOMA2-IR) standardized technique. Average number of night awakenings was positively correlated with BMI (r= 0.22, p 0.001) and negatively associated with logged HOMA2-IR (r= -0.16, p = 0.04). Path analysis demonstrated night awakenings were directly associated with BMI and indirectly associated with insulin resistance, whilst considering BMI as a potential mediator (p 0.05). Sleep duration was not associated with BMI or insulin resistance (p 0.05). Sleep quality, not sleep duration, plays an important role in insulin resistance in newly diagnosed type 2 diabetes mellitus patients. BMI may mediate the relationship between indicators of sleep quality and insulin resistance. There is a need to examine the impact of improving sleep quality on obesity and insulin resistance in patients with type 2 diabetes mellitus.
机译：为了检查睡眠时间和质量与胰岛素抵抗的直接和间接关联，考虑将体重指数（BMI）作为新诊断的2型糖尿病患者的潜在介体。来自参加糖尿病早期活动研究的患者的横断面数据。我们研究了522名新诊断的2型糖尿病患者，其中男性占65.9％，平均年龄63.5±10.1岁。在全部样品中，有53％的BMI为？30 kg / m2。参与者完成了为期7天的睡眠日记和睡眠问卷。得出平均睡眠时间（分钟），平均午睡时间（分钟）和平均夜间醒来次数。计算BMI（kg / m2）可获得身高和体重的客观测量值。使用稳态模型评估-胰岛素抵抗（HOMA2-IR）标准化技术获得了胰岛素抵抗。夜间平均唤醒次数与BMI正相关（r = 0.22，p 0.001），与日志记录的HOMA2-IR负相关（r = -0.16，p = 0.04）。路径分析表明，夜间觉醒与BMI直接相关，与胰岛素抵抗间接相关，同时将BMI作为潜在的介导因子（p 0.05）。睡眠时间与BMI或胰岛素抵抗无关（p> 0.05）。在新诊断的2型糖尿病患者中，睡眠质量而非睡眠时间在胰岛素抵抗中起着重要作用。 BMI可能介导睡眠质量指标与胰岛素抵抗之间的关系。有必要检查改善睡眠质量对2型糖尿病患者肥胖和胰岛素抵抗的影响。

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