目的 探讨结直肠癌患者术前C反应蛋白(CRP)值与肿瘤病理分期之间的关系.方法 回顾性研究经术后病理诊断为结直肠癌或结直肠腺瘤的310例患者术前3d的CRP值,分析术前CRP水平与肿瘤病理分期之间的关系.结果 CRP值在肿瘤TNM分期、T分期、N分期和M分期中均有统计学意义(P＜0.05),同时CRP值在发生局部淋巴结转移患者的术前检测中呈现高水平状态(CRP≥5.00mg/L).其中,高炎症因子CRP预测淋巴结转移准确率为63.76％,敏感度为44.44％,特异度为85.82％.采用Kappa诊断一致性检验Kappa值为0.294,P＜0.05.而且高CRP值与肿瘤分化程度和组织学类型有关(P＜0.05).结论 术前CRP值与肿瘤病理分期有关,且和肿瘤的淋巴结转移有一定的关系,高CRP值可能提示结直肠癌的淋巴结转移,因此可以将其运用于预测结直肠癌的淋巴结转移.%Objective To evaluate the value of C-reactive protein level to the preoperative staging of colorectal cancer. Methods 310 patients pathologically proved colorectal cancer or denoma were analyzed the relationships between the C-reactive protein level on 3d before operation measured preoperatively and pathological stages postoperatively. Results There were statistic differences of fibrinogen in T. N, M stages (P<0. 05). Moreover, the CRP level was higher in patients who had the lymph node metastasis (P<0. 05). In hyper-CRP (CRP≥5.00mg/L). the accuracy, sensitivity and specificity of prediction to lymphatic metastasis were 63. 76% " 44. 44% and 85. 82%, respectively. The level of CRP was related to the tumor differentiation and histological type. Conclusion The expressed level of CRP is related with the colorectal cancer stage and lymphatic metastasis. Hyper-CRP can be used as an effective predictor of lymphatic metastasis in colorectal cancer.
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