Objective To study the expression of Notch-1 in gastric carcinoma and its relationship with the expression of p53 and Ki-67. Methods Immunohistochemical staining was applied to measure the expression of Notch-1,p53 and Ki-67 in the carci⁃noma tissues and pericarcinomatous tissues. And the correlation among the expression of Notch -1, p53 and Ki -67 was analyzed. Results The positive expression rates of Notch-1,p53 and Ki-67 in gastric carcinoma group were respectively 57. 5% (48/80), 47. 5% (38/80) and 52. 5% (42/80),remarkably higher than those in the pericarcinomatous group (28. 1%,0% and 12. 5% respec⁃tively,P<0. 05) and were significantly correlated with differentiation grade and vessel invasion (P<0. 05 or P<0. 05). The expression of p53 and Ki-67 was closely correlated with lymph nodes metastasis (P<0. 05). However,Notch-1 expression was not statistically correlated with depth of invasion and lymph nodes metastasis (P>0. 05). The expression of Notch-1 was positively correlated with the expression of p53 and Ki-67. Conclusion The expression of Notch-1 and p53 may play a synergetic role in gastric cancer incidence and development. Combined detection of Notch-1,p53 and Ki-67 might be an important prognostic marker of gastric cancer.%目的：探讨不同生物学特性胃癌中Notch－1基因与p53蛋白、Ki－67表达的意义。方法采用免疫组织化学染色方法检测胃癌及其癌旁组织中的Notch－1、p53、Ki－67的表达，进行相关性分析。结果 Notch－1、p53、Ki－67在胃癌组织中的阳性表达率分别为57．5％（48／80）、47．5％（38／80）、52．5％（42／80），均明显高于癌旁组（分别为28．1％、0％、和12．5％，P＜0．05），并且都与肿瘤分化程度、脉管浸润明显呈正相关（P＜0．05）；p53、Ki－67与淋巴结转移明显相关（P＜0．05），但Notch－1与肿瘤浸润深度、淋巴结转移无明显相关性（P＞0．05）；Notch－1与p53、Ki－67表达均有高度正相关性。结论 Notch－l与p53在胃癌的进展中可能共同起作用，联合检测Notch－1、p53、Ki－67可能成为胃癌患者预后判断重要参考指标。
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