目的 分析探讨EB病毒感染的患儿临床表现、实验室检查结果,从而为临床治疗提供可行的帮助和参考.方法 选择我院2016年1月至2017年12月收治的195例EB病毒感染的患儿作为本次研究的研究对象,按照年龄分为0~12个月组、13~24个月组、25~36个月组、37~48个月组以及>48个月组5个组别.分别对各组患儿的临床资料进行回顾性分析,总结EB病毒感染的临床特点,对患儿的年龄、性别、体征、外周血常规、异型淋巴细胞比例、肝功能、心肌酶谱、C反应蛋白以及EBV-DNA拷贝数进行比较分析.结果 ①EB病毒感染的患儿临床症状主要为发热31.3%、血小板减少症25.6%、淋巴结炎9.7%、呼吸道感染9.2%等.②就诊患儿男女比例为1.5:1,主要集中在13~24个月组与>48个月组.③实验室检查结果发现,淋巴细胞比例增高者157例(80.5%)、血小板计数<50×109/L者56例(28.7%)、丙氨酸转氨酶(ALT)增高者68例(34.9%)、天冬氨酸转氨酶(AST)增高者74例(37.9%)、肌酸激酶同工酶(CKMB)增高者23例(11.8%)、CRP>10者79例(40.5%)、出现异型淋巴细胞93例(47.7%).④ALT、AST、ALP、GGT与EBV-DNA具有较高的相关性.⑤按性别分组和年龄段分组比较分析各组EBV-DNA的拷贝数差异无统计学意义.结论 邯郸地区EB病毒感染的患儿性别比例总体男性高于女性;好发年龄为13~24个月,以及>48个月2个年龄段,临床表现呈多样性;实验室检查ALT、AST、ALP、谷氨酰胺转肽酶(GGT)可以在一定程度上反应肝功能的受损程度.%Objective To analyze the clinical manifestation and the results of laboratory examination in the children with the EB virus infection.Methods One hundred and ninty-five children with EBV infection who re-ceived the inpatient treatment in our hospital from January 2016 to December 2017 were chosen as the research subjects.The children were divided into five groups according to age:0 to 12 months old,13 to 24 months old,25 to 36 months old,37 to 48 months old,>48 months old.We conducted retrospective analysis of the clinical data of the 195 children,including the gender,age,symptoms,signs,peripheral bloods,abnormal lymphocyte ratio and liver function,myocardial enzyme spectrum,CRP and EBV-DNA copies.Results ①The main clinical symptoms of EB virus infection are 31.3% of fever,25.6% of thrombocytopenia,9.7% of lymphadenitis,9.2% of respira-tory tract infection;②The ratio of the male to female is 1.5:1;mainly in the 13-24 months old group and the >48months years olds group;③The laboratory examination results:157 cases(80.5%)with the high lymphocyte proportion,56 cases(28.7%)of platelet <50×109/L,68 cases(34.9%)of high ALT,74 cases(37.9%)of high AST,23 cases(11.8%)of high CK-MB,79 cases(40.5%)of high CRP,93 cases of heterotypic lympho-cytes(47.7%);④ALT,AST,ALP,GGT were highly correlated with EBV-DNA copies;⑤There are no signif-icant difference in copies of EBV-DNA among each group according to sex and age grouping.Conclusion EB virus infects more males than females in Handan;the age of onset are 13-24 months old and >48 months old;The clini-cal manifestations of EBV infection are various.The elevation of ALT,AST,ALP,and GGT can reflect the de-gree of impaired liver function in a certain extent.
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