Objective To evaluate the screening methods of different cervical cancer .Methods Nine hun-dred and forty-three cases of TCT and /or HPV were performed with colposcopic biopsy .The results were as fol-lows :TCT and HPV were divided into five groups :group A :TCT positive alone ;group B :HR-HPV qualitative positive TCT negative ;group C :quantitative positive TCT negative ;group D :TCT combined with HR-HPV qualitative positive ;E group:TCT combined with HPV quantitative positive ,evaluation of five groups of cervical lesions screening value .Results The detection rate of CIN Ⅰ in group A was 23.41% ,while that of ≥CIN Ⅱwas only 7.31% .The detection rate of CIN Ⅰ in group B was 38.05% and CINⅡ was 14.17% .The detection rate of CINⅠ in group C was 37.57% ,and CINⅡ was 26.11% .The detection rate of CIN Ⅰ in group D was 35.26% ,≥CINⅡ 20.98% .The detection rate of CIN Ⅰ in group E was 28.33% ,≥CINⅡ 50.21% .There was significant difference between group A and the other four groups ( P<0.05) ,but there was no significant differ-ence in multiple comparison of three groups B ,C ,D ,respectively ( P>0.05) .However ,B ,C and D respective-ly ,were statistically significantly different from E group ( P<0.05) .The positive rates of biopsy ,were 30.73% , 52.23% ,63.69% ,56.25% ,and 78.54% ,in group A ,B ,C ,D and E ,respectively .The difference was statisti-cally significant ( P <0 .05) .Conclusion TCT combined with HPV quantitative screening is the most valuable screening program for cervical cancer screening .%目的 评价不同宫颈癌的筛查方法.方法 对943例液基薄层细胞学检查(TCT)和(或)乳头瘤病毒(HPV)结果异常行阴道镜活检的患者以病理结果为金标准,根据TCT及HPV结果分五组:A组:单独TCT阳性;B组:高危型(HR)-HPV定性阳性TCT阴性;C组:HPV定量阳性TCT阴性;D组:TCT联合HR-HPV定性均阳性;E组:TCT联合HPV定量均阳性,评价5组对宫颈病变筛查的价值.结果 A组病理结果宫颈上皮内瘤样病变(CIN)Ⅰ检出率23.41%,而≥CINⅡ仅7.31%;B组CINⅠ检出率38.05%,≥CINⅡ14.17%;C组CINⅠ检出率37.57%,≥CINⅡ26.11%;D组CINⅠ检出率35.26%,≥CINⅡ20.98%;E组CINⅠ检出率28.33%,而≥CINⅡ50.21%.A组与其余4组比较差异有统计学意义(P<0.05),B、C、D组之间两两比较差异均无统计学意义(P>0.05),但其均与E组比较差异有统计学意义(P<0.05).活检阳性率比较的结果A、B、C、D、E分别是30.73%、52.23%、63.69%、56.25%、78.54%,差异有统计学意义(P<0.05).结论 TCT联合HPV定量筛查是目前宫颈癌筛查方法中最有价值的筛查方案.
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