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首页> 外文期刊>British Journal of Cancer >Different cervical cancer screening approaches in a Chinese multicentre study
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Different cervical cancer screening approaches in a Chinese multicentre study

机译：中国多中心研究中不同的宫颈癌筛查方法

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To evaluate alternative cervical cancer screening methods, digital colposcopy and collection of cervical exfoliated cells for liquid-based cytology (LBC) and hybrid capture 2 (HC2) testing were performed among 2562 women aged 15–59 years in three study sites in the People's Republic of China (rural Shanxi province, Shenyang city in Liaoning province and Shenzhen city in Guangdong province). Visual inspection with acetic acid (VIA) was also evaluated independently from colposcopy. A total of 74 cases of histologically confirmed cervical intraepithelial neoplasia grade 2 or worse (CIN2+) were identified, and 16 CIN2+ cases were imputed among unbiopsied women to correct for verification bias. Corrected sensitivity for CIN2+ was 37% for VIA, 54% for colposcopy, 87% for LBC with a threshold of atypical cells of undetermined significance (LBCASCUS), 90% for HC2, 84% for LBC using HC2 to triage ASCUS and 96% for positivity to LBCASCUS or HC2. For VIA, sensitivity was much lower among women 40 years (12%) than those aged 39 years (50%). Specificity varied from 77% for positivity to LBCASCUS or HC2, up to 94% for LBC using HC2 to triage ASCUS. In conclusion, LBC, HC2 and their combinations performed well, whereas VIA missed a majority of CIN2+, particularly in older women. Digital colposcopy performed better than VIA, but still missed nearly half of CIN2+ in this study.
机译：为了评估其他宫颈癌筛查方法，在中华人民共和国的三个研究地点对2562名15-59岁的女性进行了数字阴道镜检查和宫颈脱落细胞的收集以进行液基细胞学（LBC）和Hybrid Capture 2（HC2）测试。中国（农村的山西省，辽宁省的沉阳市和广东省的深圳市）。乙酸（VIA）的目视检查也独立于阴道镜进行评估。总共确定了74例经组织学证实为2级或更差的宫颈上皮内瘤变（CIN2 +），并在未进行活检的女性中推算了16例CIN2 +病例，以纠正验证偏倚。校正后的CIN2 +敏感性对于VIA为37％，对于阴道镜检查为54％，对于具有非典型意义的阈值的非典型细胞（LBCASCUS）为87％，对于HC2为90％，使用HC2对ASCUS分流的LBC为84％对LBCASCUS或HC2呈阳性。对于VIA，40岁女性（12％）的敏感性远低于39岁女性（50％）。特异性从对LBCASCUS或HC2阳性的77％变化到对使用HC2对ASCUS进行分类的LBC的94％。总之，LBC，HC2及其组合表现良好，而VIA错过了大多数CIN2 +，特别是在老年妇女中。数字阴道镜检查的效果优于VIA，但在这项研究中仍漏掉了近一半的CIN2 +。

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