Purpose To investigate the structur e-function relationship between optical coherence tomograp hy(OCT)macular retinal and peripapillary nerve fib er layer(NFL)thick-ness and automated visual field(VF)findings.Design Cross-sectional observational stu dy.Methods Retrospective institutional study where 150conse cutive eyes(101sub-jects)from a glaucoma service were included.All the participants had full ophthalmic ev aluation,VF testing and prototype OCT scanning at the sam e visit.Orthogonal OCT macular analysis was obtained to maximize the sam-pling of the area of interest.Pearso n age-adjusted corre-lation was determined between macul ar retinal thickness and peripapillary NFL thickness.Ar ea under the receiver operator characteristics(AROC)curves for the association between macular retinal thickness a nd peripapillary NFL thickness and VF findings were calcu lated in a subgroup of eyes without VF defect and eyes wit h VF defect con-fined to one hemifield.Results The c orrelation between macular retinal and peripapillary N FL measurements ranged between r=0.27to 0.54for quadrants,0.44to0.55for hemiretina,and 0.52for the overall mean.Areas under the receiver operator characteristics for macular thickness were higher in areas corre sponding to the VF defect location than the noncorresp onding locations.Areas under the receiver operator characteristics for peripapillaryNFL thickness were higher than for th e macular retinal thickness.Including both macular r etinal thickness and peripapillary NFL thickness measur ements in the logistic regression model yielded AROCs (range:0.69-0.77)similar to those found for the peripapillary NFL alone.Conclusion Macular retinal thickness,as measured by OCT,was capable of detecting glaucomatous damage and corresponded with peripapillary NFL thickness;however,peripapillary NFL thickness had hig her sensitivity and specificity for the detection of VF a bnormalities.
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