ObjectiveTo investigate the value of application of biochemical marker of bone turnover in the early diagnosis of renal osteodystrophy in patients with chronic kidney disease.MethodsA total cases of 78 patients with chronic kidney disease and 46 healthy peoples were included in this study.The serum levels of total procollagen typeⅠamino-terminal propeptide(TPINP),β-isomerized carboxyterminal propeptide (β-CTx),intact parathyroid hormone(iPTH),and serum 1,25-dihydroxyvitamin D3[1,25-(OH)2D3] were measured,then the difference among them was be compared.ResultsThe serum levels of TPINP,β-CTx and iPTH in the patients with CKD group was significantly higher then the healthy subjects(均P<0.01),the serum 1,25-(OH)2D3 level in the CKD group was significantly decreased compared with that in the control(P<0.01).ConclusionThe application of periodic monitor the bone turnover markers were useful for the early diagnosis of renal osteodystrophy in patients with chronic kidney disease.%目的：观察骨转换标志物对慢性肾脏病患者并发骨营养不良的早期诊断价值。方法分别检测78例慢性肾脏病患者和46例健康成人血清中骨转换标志物总Ⅰ型前胶原氨基端延长肽（TPINP）、Ⅰ型胶原羧基端肽β特殊序列（β-CTx）、完整甲状旁腺素（iPTH）及血清1，25-二羟维生素D3[1，25-（OH）2D3]水平，并比较其差异性。结果慢性肾脏病并发骨营养不良患者血清TPINP、β-CTx及iPTH水平均显著高于正常对照组（P均<0.01），而血清1，25-（OH）2D3水平则显著低于对照组（P<0.01）。结论对慢性肾脏病患者定期进行骨转换标志物监测，有助于肾性骨营养不良的早期诊断。
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