Objective To investigate the effect of Xuebijing injection combined with atuomulan on the inflammatory response in patients with septic shock.Methods Sixty five patients with septic shock were divided into study group (n=33) and control group(n=32).All patients were treated with conventional anti-infection and anti-shock therapy;the control group received atuomulan,and the study group received atuomulan with Xuebijing injection.The levels of CRP,PCT,MCP-1,MIP-2 and LA were measured before and after treatment,and also compared between the two groups.Acute physiology and chronic health score (APACHE) was used to evaluate the health status of patients,and the systemic infection status was assessed by systemic infection associated organ failure (SOFA).Results the CRP,PCT,MCP-1,MIP-2 levels after treatment were significantly lower than those before treatment in both groups (P＜0.05);while the CRP,PCT,MCP-1 and MIP-2 levels after treatment in the study group were significantly lower than those in the control group (P＜0.05).The scores of LA,APACHE and SOFA after treatment were significantly lower than those before treatment in both groups (P＜0.05);while the scores were after treatment in study group significantly lower than those in the control group (P＜0.05).The efficacy of study group was significantly better than that of control group (P＜0.05).Conclusion Xuebijing injection combined with atuomulan can significantly reduce inflammation and has definite therapeutic effect in patients with septic shock.%目的 探讨血必净注射液联合阿拓莫兰对感染性休克患者炎症反应的影响.方法 将65例感染性休克患者按照序列号法分为观察组33例和对照组32例.均给予常规抗感染、抗休克治疗,对照组采用阿拓莫兰治疗,观察组在对照组基础上加用血必净注射液.对比两组患者治疗前后C反应蛋白(CRP)、降钙素原(PCT)、单核细胞趋化蛋白-1(MCP-1)、巨噬细胞炎性蛋白-2(MIP-2)、乳酸(LA)的水平.采用急性生理学和慢性健康评分(APACHEⅡ)评估患者健康状态.采用全身性感染相关性器官功能衰竭(SOFA)评价患者全身感染状态.结果 两组患者治疗后CRP、PCT、MCP-1、MIP-2水平较治疗前均明显降低(均P＜0.05);治疗后,观察组CRP、PCT、MCP-1、MIP-2水平明显低于对照组,差异均有统计学意义(均P＜0.05);两组患者治疗后LA水平、APACHElI评分、SOFA评分较治疗前均明显降低(均P＜0.05);治疗后,观察组LA水平、APACHE Ⅱ评分、SOFA评分明显低于对照组,差异均有统计学意义(均P＜0.05);观察组的疗效显著优于对照组,差异有统计学意义(P＜0.05).结论 血必净注射液联合阿拓莫兰治疗感染性休克的疗效确切,能显著减轻炎症反应,提高治疗效果.
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