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Cefonicid as Therapy for Uncomplicated Gonococcal Urethritis Caused by Penicillinase-Producing Neisseria gonorrhoeae

机译:头孢类抗生素治疗由青霉素酶引起的淋病奈瑟氏球菌引起的复杂性淋球菌性尿道炎

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摘要

Young men with uncomplicated gonococcal urethritis were treated with 1 gram of cefonicid given intramuscularly plus 1 gram of probenecid by mouth. Of 53 evaluable patients, 33 (62%) had penicillinase-producing Neisseria gonorrhoeae. All but one of these patients were cured. All men who had penicillin-sensitive infections were cured. Cefonicid was highly effective in the treatment of both penicillin-sensitive and penicillin-resistant N gonorrhoeae. Other than moderate pain at the site of injection, there were no adverse side effects. Cefonicid can be added to the group of newer cephalosporins that are effective in the treatment of gonococcal urethritis caused by either penicillin-sensitive or penicillin-resistant strains.
机译:对患有单纯性淋球菌性尿道炎的年轻男性,肌肉注射1克头孢尼加1克丙磺舒口服。在53名可评估的患者中,有33名(62%)患有产生青霉素酶的淋病奈瑟氏球菌。除一名患者外,所有患者均已治愈。所有对青霉素敏感的感染者均已治愈。头孢尼西德对青霉素敏感和耐青霉素的淋病奈瑟球菌都非常有效。除了注射部位的中度疼痛外,没有不良副作用。可以将头孢尼类添加到新型头孢菌素中,这些头孢菌素可有效治疗由对青霉素敏感或对青霉素敏感的菌株引起的淋球菌性尿道炎。

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