• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>Canadian Journal of Gastroenterology >Pancreatic Enzyme Supplements Are Not Effective for Relieving Abdominal Pain in Patients with Chronic Pancreatitis: Meta-Analysis and Systematic Review of Randomized Controlled Trials
【2h】

Pancreatic Enzyme Supplements Are Not Effective for Relieving Abdominal Pain in Patients with Chronic Pancreatitis: Meta-Analysis and Systematic Review of Randomized Controlled Trials

机译：胰酶补充剂对缓解慢性胰腺炎患者的腹痛无效：荟萃分析和系统评价随机对照试验

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background. Pancreatic enzyme supplementation is widely used to treat pain in patients with chronic pancreatitis, despite little evidence for efficacy. We performed a systematic review of the literature and a meta-analysis to investigate its effectiveness. Methods. All randomized controlled parallel or crossover trials in patients with chronic pancreatitis comparing pancreatic enzyme supplementation to placebo were included. The main outcome was improvement in pain score or reduced analgesic consumption. Two independent reviewers extracted data. Mantel-Haenszel random effect model meta-analysis was used whenever methodologically appropriate. Results. Five out of 434 retrieved studies were included in the systematic review. All studies used relatively similar methodology. Four studies using enteric-coated pancreatic enzyme supplementation failed to show any improvement in pain as compared to placebo. The only study using non-enteric-coated enzymes did show reduction in the pain score. There was significant heterogeneity among studies in both analyses. Random model meta-analysis of three studies showed no significant difference in the mean of daily pain score (mean difference: 0.09 (1.57–1.39), p = 0.91) or average weekly analgesic consumption (mean difference: −0.30 (−2.37–1.77), p = 0.77) between the periods of administering pancreatic enzyme supplementation versus placebo. Conclusion. Pancreatic enzyme supplements do not seem to relieve abdominal pain in patients with chronic pancreatitis and should not be prescribed solely for this purpose, given their significant cost and potential side effects.
机译：背景。尽管尚无有效证据，但补充胰酶已广泛用于治疗慢性胰腺炎患者的疼痛。我们对文献进行了系统的综述，并进行了荟萃分析以研究其有效性。方法。所有慢性胰腺炎患者的随机对照平行或交叉试验均比较了补充胰酶和安慰剂的情况。主要结果是疼痛评分改善或止痛药减少。两名独立的审阅者提取了数据。只要方法论适当，就使用Mantel-Haenszel随机效应模型的荟萃分析。结果。 434篇检索研究中有5篇纳入系统评价。所有研究均使用相对相似的方法。与安慰剂相比，使用肠溶性胰酶补充剂进行的四项研究未能显示疼痛得到任何改善。唯一使用非肠溶酶的研究确实显示疼痛评分降低。在两项分析中，研究之间存在明显的异质性。对三项研究的随机模型荟萃分析显示，每日疼痛评分的平均值（均值差异：0.09（1.57–1.39），p = 0.91）或每周平均镇痛剂用量（均值差异：−0.30（−2.37–1.77）无显着差异），在补充胰酶与安慰剂之间，p = 0.77）。结论。胰腺酶补充剂似乎不能减轻慢性胰腺炎患者的腹痛，并且鉴于其昂贵的成本和潜在的副作用，不应仅为此目的而开处方。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号