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首页> 美国卫生研究院文献>Clinical and Diagnostic Laboratory Immunology >Genetic Variation at the Mitochondrial Large-Subunit rRNA Locus of Pneumocystis Isolates from Simian Immunodeficiency Virus-Infected Rhesus Macaques
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Genetic Variation at the Mitochondrial Large-Subunit rRNA Locus of Pneumocystis Isolates from Simian Immunodeficiency Virus-Infected Rhesus Macaques

机译：猿猴免疫缺陷病毒感染恒河猴的肺孢子虫线粒体大亚基rRNA基因座的遗传变异。

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摘要

The nucleotide sequences of a segment of the Pneumocystis mitochondrial large-subunit (mt LSU) rRNA gene from rhesus macaques coinfected with simian immunodeficiency virus (SIV) and Pneumocystis carinii were examined. Of 12 isolates examined, 3 were found to be identical and the others showed substantial sequence variation, with up to 13% divergence among variants. We identified two general sequence types that differed at several sites, including a conserved 26-nucleotide insertion. Four monkeys had evidence of two Pneumocystis variants present simultaneously, indicative of a mixed infection. There was a high degree of variance between the rhesus macaque-derived Pneumocystis mt LSU rRNA gene sequence and the cognate sequences in Pneumocystis organisms derived from other hosts. Analysis of the mt LSU rRNA genes of Pneumocystis organisms derived from rhesus macaques and several other mammalian hosts supports the observation that rhesus macaque-derived Pneumocystis is most closely related to human-derived Pneumocystis. In addition, the data identify the mt LSU rRNA gene as an informative locus for transmission and epidemiological studies of the SIV-rhesus macaque model of Pneumocystis infection.
机译：检查了与猿猴免疫缺陷病毒（SIV）和卡氏肺孢子虫共感染的恒河猴猕猴线粒体线粒体大亚基（mt LSU）rRNA基因片段的核苷酸序列。在检查的12个分离株中，发现3个是相同的，其他分离株显示出实质的序列变异，变异之间的差异高达13％。我们鉴定了在几个位点不同的两种通用序列类型，包括保守的26个核苷酸插入。四只猴子有两个同时存在的肺孢子虫变种的证据，表明存在混合感染。恒河猴猕猴肺孢子虫mt LSU rRNA基因序列与其他寄主肺孢菌的同源序列之间存在高度差异。对源自恒河猴和其他几种哺乳动物宿主的肺孢子虫微生物mt LSU rRNA基因的分析支持以下观察：恒河猴衍生的肺孢子虫与人类衍生的肺孢子菌最相关。此外，数据将mt LSU rRNA基因鉴定为肺囊虫感染的SIV-猕猴模型的传播和流行病学研究的信息源。

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