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首页> 美国卫生研究院文献>Current Controlled Trials in Cardiovascular Medicine >A multicenter randomized controlled open-label trial to assess the efficacy of compound kushen injection in combination with single-agent chemotherapy in treatment of elderly patients with advanced non-small cell lung cancer: study protocol for a randomized controlled trial
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A multicenter randomized controlled open-label trial to assess the efficacy of compound kushen injection in combination with single-agent chemotherapy in treatment of elderly patients with advanced non-small cell lung cancer: study protocol for a randomized controlled trial

机译：多中心随机对照开放标签试验评估复方苦参注射液与单药化疗联合治疗老年晚期非小细胞肺癌的疗效：一项随机对照试验的研究方案

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BackgroundWith the aging of the global population, an increasing number of elderly are diagnosed with advanced non-small cell lung cancer. Although systematic chemotherapy has been one of the primary treatments for advanced non-small cell lung cancer worldwide, the elderly cannot always tolerate standard platinum-based doublet chemotherapy, thus resulting in treatment failure. To reduce toxicity, single-agent chemotherapy is often used to treat the elderly with non-small cell lung cancer; however, this may increase the risk of treatment failure due to an inadequate dose. It has been shown that compound kushen injection in combination with chemotherapy can enhance the efficacy and reduce the toxicity. The aim of this trial is to assess the clinical effectiveness and safety of compound kushen injection in combination with single-agent chemotherapy versus platinum-based doublet chemotherapy in the treatment of elderly patients with advanced non-small cell lung cancer.
机译：背景技术随着全球人口的老龄化，越来越多的老年人被诊断出患有晚期非小细胞肺癌。尽管系统化学疗法已经成为全世界晚期非小细胞肺癌的主要治疗方法之一，但是老年人不能总是耐受标准的铂基双线化疗，从而导致治疗失败。为了降低毒性，单药化疗通常用于治疗非小细胞肺癌的老年人。但是，这可能会由于剂量不足而增加治疗失败的风险。研究表明，复方苦参注射液联合化疗可以增强疗效，降低毒性。该试验的目的是评估复方苦参注射液联合单药化疗和铂类双线化疗在老年晚期非小细胞肺癌患者中的临床疗效和安全性。

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