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Progression to bone-marrow carcinomatosis and extraosseous legion during treatment with radium-223 for multiple bone metastases

机译:镭223治疗多发性骨转移期间进展为骨髓癌和骨外军团

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摘要

A 67-year-old man with metastatic prostate cancer presented with progression to castration-resistant prostate cancer. After sequential therapies with flutamide, estramustine phosphate, docetaxel, enzalutamide, and cabazitaxel for castration-resistant prostate cancer, radium-223 was initiated and continued up to 4 cycles. However, concurrently with radiological and clinical progressions, pancytopenia was observed due to bone-marrow carcinomatosis by prostatic adenocarcinoma. This case suggested that radium-223 should be employed at appropriated timing before appearances of extraosseous and bone-marrow lesions in addition to visceral metastasis.
机译:一名67岁的转移性前列腺癌患者表现为去势抵抗性前列腺癌。在依次使用氟他胺,磷酸雌莫司汀,多西紫杉醇,恩杂鲁胺和卡巴他赛治疗去势抵抗性前列腺癌后,开始使用镭223,并持续多达4个周期。然而,在放射学和临床进展的同时,由于前列腺腺癌的骨髓癌变而观察到全血细胞减少。该病例提示,除了内脏转移外,还应在出现骨外和骨髓病变之前的适当时间使用镭223。

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