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Batch effect exerts a bigger influence on the rat urinary metabolome and gut microbiota than uraemia: a cautionary tale

机译：与尿毒症相比间歇效应对大鼠尿中代谢组和肠道菌群的影响更大：一个警示故事

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BackgroundRodent models are invaluable for studying biological processes in the context of whole organisms. The reproducibility of such research is based on an assumption of metabolic similarity between experimental animals, controlled for by breeding and housing strategies that minimise genetic and environmental variation. Here, we set out to demonstrate the effect of experimental uraemia on the rat urinary metabolome and gut microbiome but found instead that the effect of vendor shipment batch was larger in both areas than that of uraemia.

机译：背景啮齿动物模型对于研究整个生物体中的生物过程具有无价的作用。此类研究的可重复性基于实验动物之间代谢相似性的假设，并通过将遗传和环境变异降至最低的繁殖和饲养策略加以控制。在这里，我们着手证明实验性尿毒症对大鼠尿代谢组和肠道微生物组的影响，但相反，发现供应商装运批次在这两个方面的影响都大于尿毒症。

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期刊名称 Microbiome
作者
David William Randall; Julius Kieswich; Jonathan Swann; Kieran McCafferty; Christoph Thiemermann; Michael Curtis; Lesley Hoyles; Muhammed Magdi Yaqoob;
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作者单位

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年(卷),期 2019(7),-1
年度 2019
页码 127
总页数 10
原文格式 PDF
正文语种
中图分类微生物学;
关键词
Microbiome Urinary metabolome sup1/supH-NMR spectroscopy Uraemia Batch effect Hippurate Lactate Acetate;

机译：微生物组;尿液代谢组;sup 1 / sup H-NMR光谱;尿毒症;分批效应;马尿酸盐;乳酸盐;乙酸盐;

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专利

1. Batch effect exerts a bigger influence on the rat urinary metabolome and gut microbiota than uraemia: a cautionary tale [J] . David William Randall, Julius Kieswich, Jonathan Swann, Microbiome . 2019,第1期

机译：批量效应对大鼠尿代谢和肠道微生物群产生更大的影响，而不是铀症：一个警示的故事
2. Influence of a cholesterol-lowering strainLactobacillus plantarumLP3 isolated from traditional fermented yak milk on gut bacterial microbiota and metabolome of rats fed with a high-fat diet [J] . Ding Zitong, Hani Anum, Li Wenyuan, Food & Function . 2020,第9期

机译：降胆固醇的肺乳杆菌的影响从传统发酵的牦牛牛奶中分离出肠道细菌微生物和高脂饮食喂养大鼠代谢物的影响
3. The glyphosate formulation Roundup® LB plus influences the global metabolome of pig gut microbiota in vitro [J] . Jannike L. Krause, Sven-Bastiaan Haange, Stephanie S. Schaepe, Science of the total environment . 2020,第Nova25期

机译：草甘膦配方Roundup®LBPlus影响猪肠道微生物的全球代谢物体外
4. Ursodeoxycholic Acid (Ursodiol) Significantly Alters the Gut Microbiota and Bile Acid Metabolome in Conventional Mice [C] . American College of Veterinary Internal Medicine Forum Conference . 2019

机译：核糖核酸（Ursodiol）在常规小鼠中显着改变肠道微生物酵母和胆汁酸代谢物
5. Gut Microbiota and Systemic Autoimmunity: Ameliorating Systemic Lupus Erythematosus through Diet, Microbiota, and Host Immune System Interactions [D] . Zegarra Ruiz, Daniel Fernando. 2018

机译：肠道菌群和全身自身免疫：通过饮食，菌群和宿主免疫系统的相互作用改善系统性红斑狼疮
6. Stratified randomization controls better for batch effects in 450K methylation analysis: a cautionary tale [O] . Olive D. Buhule, Ryan L. Minster, Nicola L. Hawley, 2014

机译：分层随机对照可更好地控制450K甲基化分析中的批次效应：一个警示故事
7. Publisher Correction: Neonatal intensive care unit (NICU) exposures exert a sustained influence on the progression of gut microbiota and metabolome in the first year of life [O] . Polly Soo Xi Yap, Chun Wie Chong, Azanna Ahmad Kamar, 2021

机译：出版商矫正：新生儿重症监护单位（NICU）曝光对生命的第一年的肠道微生物群和代谢物的进展产生了持续影响

Batch effect exerts a bigger influence on the rat urinary metabolome and gut microbiota than uraemia: a cautionary tale

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