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首页> 外文期刊>Food & Function >Influence of a cholesterol-lowering strainLactobacillus plantarumLP3 isolated from traditional fermented yak milk on gut bacterial microbiota and metabolome of rats fed with a high-fat diet
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Influence of a cholesterol-lowering strainLactobacillus plantarumLP3 isolated from traditional fermented yak milk on gut bacterial microbiota and metabolome of rats fed with a high-fat diet

机译：降胆固醇的肺乳杆菌的影响从传统发酵的牦牛牛奶中分离出肠道细菌微生物和高脂饮食喂养大鼠代谢物的影响

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摘要

L. plantarumLP3 isolated from traditinal fermented Tibetan yak milk has been identified as a potential probiotic candidate strain with high cholesterol-lowering activity. In this study, thirty Sprague-Dawley (SD) rats were randomly divided into three groups, including normal diet (NC), high-fat diet (HC), and high-fat diet +L. plantarumLP3 (HLp). The effects ofL. plantarumLP3 on plasma lipid profile, gut bacterial microbiota, and metabolome induced by high-fat diet in rats were investigated. Results shown thatL. plantarumLP3 administration was found to reduce the levels of total cholesterol, triglyceride, and low-density lipoprotein cholesterol (LDL-C) and atherogenic index in the serum of high-fat diet rats. It also controlled the decrease ofBacteroidetesand increase ofFirmicutesat the phylum level in gut microbiota induced by high-fat diet in SD rats and increased the diversity and relative abundance of intestinal flora in obese rats. In particular, the LP3 strain controlled the changes induced by the high-fat diet in the abundance of forLachnospiraceaeandErysipelotrichaceae. We also further observed the beneficial regulatory effects ofL. plantarumLP3 on changes in the levels of obesity-related metabolites. The biosynthesis of fatty acids, steroids, and bile acids and metabolism of linoleic acid, linolenic acid, and arachidonic acid were the main metabolic pathways adjusted byL. plantarumLP3 in obese rats, and the metabolic rates were similar to those observed in normal diet rats levels. The findings of this study provided useful information on the mechanism underlying the hypocholesterolemic effects ofL. plantarumLP3 in the high-fat induced SD rat model with the perspective of modulation of gut microbiota and metabolites.
机译：L.从交流发酵藏牦牛牛奶中分离的Plantarumlp3已被鉴定为具有高胆固醇的活性的潜在益生菌候选菌株。在本研究中，三十天的Sprague-Dawley（SD）大鼠随机分为三组，包括正常饮食（NC），高脂饮食（HC）和高脂饮食+ L. plantarumlp3（HLP）。效果。研究了Plantarumlp3在血浆脂质型材，肠道细菌微生物瘤和大鼠高脂饮食中诱导的代谢物。结果显示了。发现Plantarumlp3给药以降低高脂饮食大鼠血清中总胆固醇，甘油三酯和低密度脂蛋白胆固醇（LDL-C）和闭体指数的水平。它还控制了在SD大鼠中高脂饮食诱导的肠道微生物的肠道水平的减少，并增加了肥胖大鼠肠道菌群的多样性和相对丰度的肠道微生物瘤的阴影水平。特别是，LP3应变控制了高脂饮食在丰富的ForlachnospiroCeaeaneIpeLotrichaceae中诱导的变化。我们还进一步观察到了对其有益的调节效应。 Plantarumlp3关于肥胖相关的代谢物水平的变化。脂肪酸，类固醇和胆汁酸的生物合成，亚油酸，亚麻酸和花生酸的代谢是通过IL调节的主要代谢途径。 Plantarumlp3在肥胖大鼠中，代谢率类似于在正常饮食大鼠水平中观察到的那些。本研究的结果提供了有关次吞噬物质效应的机制的有用信息。 Plantarumlp3在高脂肪诱导的SD大鼠模型中，具有肠道微生物和代谢物的调节的视角。

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  • 来源
    《Food & Function》 |2020年第9期|共12页
  • 作者

    Ding Zitong; Hani Anum; Li Wenyuan; Gao Lie; Ke Wencan; Guo Xusheng;

  • 作者单位

    Lanzhou Univ Sch Life Sci State Key Lab Grassland &

    Agroecosyst Lanzhou 730000 Peoples R China;

    Lanzhou Univ Sch Life Sci State Key Lab Grassland &

    Agroecosyst Lanzhou 730000 Peoples R China;

    Lanzhou Univ Sch Life Sci State Key Lab Grassland &

    Agroecosyst Lanzhou 730000 Peoples R China;

    Lanzhou Univ Sch Life Sci State Key Lab Grassland &

    Agroecosyst Lanzhou 730000 Peoples R China;

    Lanzhou Univ Sch Life Sci State Key Lab Grassland &

    Agroecosyst Lanzhou 730000 Peoples R China;

    Lanzhou Univ Sch Life Sci State Key Lab Grassland &

    Agroecosyst Lanzhou 730000 Peoples R China;

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  • 正文语种 eng
  • 中图分类 食品工业;
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