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首页> 美国卫生研究院文献>Genes >Genome-Wide Analysis of the Zn(II)2Cys6 Zinc Cluster-Encoding Gene Family in Tolypocladiumguangdongense and Its Light-Induced Expression
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Genome-Wide Analysis of the Zn(II)2Cys6 Zinc Cluster-Encoding Gene Family in Tolypocladiumguangdongense and Its Light-Induced Expression

机译：Tolypocladium中的Zn（II）2Cys6锌簇编码基因家族的全基因组分析广东话及其光诱导表达

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摘要

The Zn(II)2Cys6 zinc cluster gene family is a subclass of zinc-finger proteins, which are transcriptional regulators involved in a wide variety of biological processes in fungi. We performed genome-wide identification and characterization of Zn(II)2Cys6 zinc-cluster gene (C6 zinc gene) family in Tolypocladium guangdongense, Cordyceps militaris and Ophiocordyceps sinensis. Based on the structures of the C6 zinc domains, these proteins were observed to be evolutionarily conserved in ascomycete fungi. We focused on T. guangdongense, a medicinal fungus, and identified 139 C6 zinc genes which could be divided into three groups. Among them, 49.6% belonged to the fungal specific transcriptional factors, and 16% had a DUF3468 domain. Homologous and phylogenetic analysis indicated that 29 C6 zinc genes were possibly involved in the metabolic process, while five C6 zinc genes were supposed to be involved in asexual or sexual development. Gene expression analysis revealed that 54 C6 zinc genes were differentially expressed under light, including two genes that possibly influenced the development, and seven genes that possibly influenced the metabolic processes. This indicated that light may affect the development and metabolic processes, at least partially, through the regulation of C6 zinc genes in T. guangdongense. Our results provide comprehensive data for further analyzing the functions of the C6 zinc genes.
机译：Zn（II）2Cys6锌簇基因家族是锌指蛋白的一个子类，锌指蛋白是涉及真菌中多种生物学过程的转录调节因子。我们在广东Tolypocladium，milyris冬虫夏草和Ophiocordyceps sinensis中进行了全基因组的Zn（II）2Cys6锌簇基因（C6锌基因）家族的鉴定和表征。基于C6锌域的结构，观察到这些蛋白质在子囊真菌中进化上保守。我们将重点放在药用真菌T. guangdongense上，确定了139个C6锌基因，这些基因可以分为三类。其中，有49.6％属于真菌特异性转录因子，有16％具有DUF3468结构域。同源和系统发育分析表明29个C6锌基因可能参与了代谢过程，而五个C6锌基因被认为与无性或性发育有关。基因表达分析表明，在光线下差异表达了54个C6锌基因，包括两个可能影响发育的基因和七个可能影响代谢过程的基因。这表明光可能通过调节广东红毛猪中的C6锌基因而至少部分地影响发育和代谢过程。我们的结果为进一步分析C6锌基因的功能提供了全面的数据。

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