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首页> 美国卫生研究院文献>Frontiers in Human Neuroscience >Altered Intermittent Rhythmic Delta and Theta Activity in the Electroencephalographies of High Functioning Adult Patients with Autism Spectrum Disorder
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Altered Intermittent Rhythmic Delta and Theta Activity in the Electroencephalographies of High Functioning Adult Patients with Autism Spectrum Disorder

机译：高功能成人自闭症谱系障碍患者脑电图中间歇性节律变化和θ活动的改变

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>Background: Autism spectrum disorder (ASD) is often associated with epilepsy. Previous studies have also shown increased rates of electroencephalographic (EEG) alteration in ASD patients without epilepsy. The aim of this study was to compare the rate of intermittent rhythmic delta and theta activity (IRDA/IRTA) events between high-functioning adult patients with ASD and matched healthy controls.>Materials and Methods: Routine EEG records of 19 ASD patients and 19 matched controls were screened for IRDA/IRTA using a fully data driven analysis with fixed thresholds. IRDA/IRTA rates before and after hyperventilation (HV) as well as the HV-induced difference in IRDA/IRTA rates (HV difference) were analyzed. For inter-group measures, we used the Wilcoxon rank sum test.>Results: Significantly increased HV difference was detected in the ASD group (p = 0.0497). However, the groups showed no difference in IRDA/IRTA rates before HV (p = 0.564) and after HV (p = 0.163).>Conclusions: The lack of any group differences regarding IRDA/IRTA before HV might be related to the fact that we only studied non-secondary high-functioning autism in a small sample of epilepsy-free adult patients. A significantly increased HV difference might be regarded as a marker of subtle neuronal network instability possibly causing short-term disturbances via local area network inhibition and long-term effects via epileptic encephalopathy.
机译：>背景：自闭症谱系障碍（ASD）通常与癫痫病相关。先前的研究还显示，没有癫痫的ASD患者的脑电图（EEG）改变率增加。这项研究的目的是比较功能正常的成人ASD患者和相匹配的健康对照者间断性节律性三角洲和theta活动（IRDA / IRTA）事件的发生率。>材料和方法：常规脑电图记录使用固定阈值的完全数据驱动的分析方法，对19位ASD患者和19位相匹配的对照进行IRDA / IRTA筛查。分析了过度换气前后的IRDA / IRTA率（HV）以及HV引起的IRDA / IRTA率差异（HV差异）。对于组间措施，我们使用Wilcoxon秩和检验。>结果：在ASD组中检测到HV差异显着增加（p = 0.0497）。但是，各组在HV之前（p = 0.564）和HV之后（p = 0.163）的IRDA / IRTA率无差异。>结论：在HV之前，关于IRDA / IRTA的任何分组均缺乏差异这与以下事实有关：我们仅在少量无癫痫成年患者中研究了非继发性高功能自闭症。 HV差异显着增加可能被认为是微妙的神经网络不稳定的标志，可能通过局域网抑制引起短期干扰，并通过癫痫性脑病引起长期影响。

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