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Design and Fabrication by Thermal Imprint Lithography and Mechanical Characterization of a Ring-Based PDMS Soft Probe for Sensing and Actuating Forces in Biological Systems

机译:通过热压印光刻技术设计和制造基于环的PDMS软探针用于生物系统中的传感和驱动力。

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摘要

In this paper, the design, fabrication and mechanical characterization of a novel polydimethylsiloxane (PDMS) soft probe for delivering and sensing forces in biological systems is proposed. On the basis of preliminary finite element (FEM) analysis, the design takes advantage of a suitable core geometry, characterized by a variable spring-like ring. The compliance of probes can be finely set in a wide range to measure forces in the micronewton to nanonewton range. In particular, this is accomplished by properly resizing the ring geometry and/or exploiting the mixing ratio-based elastic properties of PDMS. Fabrication by the thermal imprint lithography method allows fast and accurate tuning of ring sizes and tailoring of the contact section to their targets. By only varying geometrical parameters, the stiffness ranges from 1080 mNm−1 to 50 mNm−1, but by changing the base-curing agent proportion of the elastomer from 10:1 to 30:1, the stiffness drops to 37 mNm−1. With these compliances, the proposed device will provide a new experimental tool for investigating force-dependent biological functions in sensory systems.
机译:在本文中,提出了一种新型的聚二甲基硅氧烷(PDMS)软探针的设计,制造和机械特性,该探针可在生物系统中传递和感应力。在初步有限元(FEM)分析的基础上,该设计利用了合适的铁芯几何形状,其特征在于具有可变的弹簧状环。探头的柔度可以在很宽的范围内进行精细设置,以测量从微牛顿到纳米牛顿范围的力。特别地,这通过适当地调整环的几何尺寸和/或利用PDMS的基于混合比的弹性特性来实现。通过热压印光刻方法进行制造,可以快速而准确地调整环的尺寸,并根据其目标定制接触部分。仅通过改变几何参数,刚度就从1080 mNm -1 到50 mNm -1 不等,但是通过将弹性体的基础固化剂比例从10:1更改为到30:1,刚度下降到37 mNm -1 。有了这些合规性,建议的设备将提供一种新的实验工具,用于研究感觉系统中依赖于力的生物学功能。

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