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首页> 美国卫生研究院文献>The Scientific World Journal >Antipsychotic-Like Effect of Trimetazidine in a Rodent Model
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Antipsychotic-Like Effect of Trimetazidine in a Rodent Model

机译：灭鼠灵在啮齿动物模型中的抗精神病样作用

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Trimetazidine (TMZ) has been used as an anti-ischemic agent for angina pectoris, chorioretinal disturbances, and vertigo. Also, it can induce extrapyramidal type adverse reaction such as parkinsonism, gait disorder, and tremor via blockade of D2 receptors. In the present study, we evaluated the effect of TMZ on novelty-induced rearing behavior and apomorphine-induced stereotypy behavior in male rats. Four groups of rat (n = 7) were administrated with TMZ (10 and 20 mg/kg, i.p.), chlorpromazine (1 mg/kg, i.p.), or isotonic saline. One hour later, apomorphine (2 mg/kg, s.c.) was administrated to each rat. Our results showed that both doses of TMZ significantly decreased the rearing behavior in rats, whereas the decrease with chlorpromazine was higher. TMZ also decreased the stereotypy scores in a dose-dependent manner. We concluded that TMZ has beneficial effects on rearing behavior and stereotypy, which are accepted to be indicators of antipsychotic effect. Taken together, with its antioxidative and cytoprotective properties, TMZ is worthy of being investigated for its anti-psychotic effects as a primary or an adjunctive drug.
机译：曲美他嗪（TMZ）已用作心绞痛，脉络膜视网膜疾病和眩晕的抗缺血药。而且，它可以通过阻断D2受体而引起锥体束外型不良反应，如帕金森氏症，步态障碍和震颤。在本研究中，我们评估了TMZ对雄性大鼠新奇诱导的饲养行为和阿扑吗啡诱导的定型行为的影响。四组大鼠（n = 7）分别接受TMZ（10和20 mg / kg，腹腔注射），氯丙嗪（1 mg / kg，腹腔注射）或等渗盐水给药。一小时后，向每只大鼠给药阿扑吗啡（2μg/ kg，皮下注射）。我们的结果表明，两种剂量的TMZ均显着降低了大鼠的饲养行为，而氯丙嗪的降低幅度更大。 TMZ还以剂量依赖性方式降低刻板印象分数。我们得出的结论是，TMZ对养育行为和定型观念具有有益作用，被认为是抗精神病作用的指标。综上所述，TMZ具有抗氧化和细胞保护特性，值得作为主要或辅助药物的抗精神病作用进行研究。

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