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首页> 美国卫生研究院文献>World Journal of Gastroenterology >Comparison of esomeprazole enteric-coated capsules vs esomeprazole magnesium in the treatment of active duodenal ulcer: A randomized double-blind controlled study
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Comparison of esomeprazole enteric-coated capsules vs esomeprazole magnesium in the treatment of active duodenal ulcer: A randomized double-blind controlled study

机译：埃索美拉唑肠溶胶囊与埃索美拉唑镁治疗活动性十二指肠溃疡的比较：一项随机双盲对照研究

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AIM: To evaluate the efficacy and tolerability of two different preparations of esomeprazole in healing duodenal ulcers.METHODS: A total of 60 patients with active duodenal ulcers were enrolled and randomized to receive esomeprazole enteric-coated capsules (40 mg) or esomeprazole magnesium (40 mg), once daily, for 4 consecutive wk, with ulcer healing being monitored by endoscopy. Safety and tolerability were also assessed.RESULTS: Fifty seven patients completed the whole trial. The ulcer healing rates at the end of wk 2 were 86.7% and 85.2% in the esomeprazole enteric-coated capsules and esomeprazole magnesium groups, respectively (P = 0.8410), and reached 100% at the end of wk 4 in both groups. Symptom relief at the end of wk 2 was 90.8% in the esomeprazole enteric-coated capsules group and 86.7% in the esomeprazole magnesium group (P = 0.5406); at the end of wk 4 symptom relief was 95.2% and 93.2%, respectively (P = 0.5786). Adverse events occurred in 16.7% of the esomeprazole enteric-coated capsules group and 14.8% of the esomeprazole magnesium group (P = 1.0000).CONCLUSION: The efficacies of esomeprazole enteric-coated capsules and esomeprazole magnesium in healing duodenal ulcer lesions and relieving gastrointestinal symptoms are equivalent. The tolerability and safety of both drugs were comparable.
机译：目的：评价两种不同的埃索美拉唑制剂在十二指肠溃疡愈合中的疗效和耐受性方法：招募60例活动性十二指肠溃疡患者并随机分配接受埃索美拉唑肠溶胶囊（40 mg）或埃索美拉唑镁（40每日一次，连续4周，内镜检查溃疡愈合情况。结果：57名患者完成了整个试验。埃索美拉唑肠溶胶囊和埃索美拉唑镁治疗组在wk 2结束时的溃疡愈合率分别为86.7％和85.2％（P = 0.8410），并且在wk 4结束时两组均达到100％。埃索美拉唑肠溶胶囊组第2周末症状缓解率为90.8％，埃索美拉唑镁治疗组为86.7％（P = 0.5406）；第4周末症状缓解率分别为95.2％和93.2％（P = 0.5786）。埃索美拉唑肠溶胶囊组发生不良事件的发生率为16.7％，埃索美拉唑镁组发生率为14.8％（P = 1.0000）。结论：埃索美拉唑肠溶胶囊和埃索美拉唑镁对十二指肠溃疡病变和胃肠道症状的缓解作用是等效的。两种药物的耐受性和安全性相当。

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