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Immunological studies in typhoid fever. I. Immunoglobulins C3 antibodies rheumatoid factor and circulating immune complexes in patients with typhoid fever.

机译:伤寒的免疫学研究。 I.伤寒患者的免疫球蛋白C3抗体类风湿因子和循环免疫复合物。

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摘要

The development of O, H and Vi antibodies to Salmonella typhi antigens, immunoglobulins and C3 levels, and the presence of rheumatoid factor and circulating immune complexes were determined in the sera of patients with typhoid fever and appropriate age and sex-matched controls. IgM, and both O and H antibodies were raised in typhoid patients. Rheumatoid factor, a possible indicator of persistent circulating immune complexes, was also present in these patients. Immune complexes were more often present in patients with typhoid fever than in controls, their presence was much more marked in complicated cases of typhoid fever. A high ratio of alpha 1-antitrypsin to C3 was found in these patients suggesting complement consumption.
机译:在伤寒患者以及适当的年龄和性别匹配的对照人群中,确定了针对鼠伤寒沙门氏菌抗原,免疫球蛋白和C3水平的O,H和Vi抗体的发展以及类风湿因子和循环免疫复合物的存在。伤寒患者体内产生了IgM和O和H抗体。这些患者中也存在类风湿因子,这可能是持续循环免疫复合物的指标。伤寒患者中的免疫复合物比对照组中更常见,在伤寒病例中,它们的存在更为明显。在这些患者中发现高比例的α1-抗胰蛋白酶与C3的比例,提示补体消耗。

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