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Design of the randomized controlled sequential staged treatment of emphysema with upper lobe predominance (STEP-UP) study

机译：具有上叶优势（STEP-UP）研究的随机受控序贯分期治疗肺气肿的设计

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摘要

BackgroundAn innovative approach to lung volume reduction (LVR) for emphysema is introduced in the design of the Sequential Segmental Treatment of Emphysema with Upper Lobe Predominance (STEP-UP) trial where vapour ablation is administered bilaterally over the course of two sessions and is used to target only the most diseased upper lobe segments. By dividing the procedure into two sessions, there is potential to increase the total volume treated per patient but reduce volume treated and energy delivered per session. This is expected to correlate with improvements in vapour ablation’s safety and efficacy profiles.

机译：背景技术肺气肿的肺容量减少（LVR）的创新方法被引入上肺叶优势序贯性肺气肿分段治疗（STEP-UP）试验的设计中，该试验在两个疗程的过程中双向进行了蒸汽消融，并用于仅针对病情最严重的上叶部分。通过将手术分为两个阶段，有可能增加每个患者的总治疗量，但减少每个阶段的治疗量和能量传递。预期这与蒸气消融的安全性和功效特征的改善相关。

著录项

期刊名称 BMC Pulmonary Medicine
作者
Arschang Valipour; Felix JF Herth; Ralf Eberhardt; Pallav L Shah; Avina Gupta; Robert Barry; Erik Henne; Sourish Bandyopadhyay; Greg Snell;
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作者单位

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年(卷),期 2014(14),-1
年度 2014
页码 190
总页数 10
原文格式 PDF
正文语种
中图分类外科学;
关键词
Vapour ablation STEP-UP Emphysema Lung volume reduction;

机译：蒸气消融;升压;肺气肿;肺体积减少;

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专利

1. Design of the randomized, controlled sequential staged treatment of emphysema with upper lobe predominance (STEP-UP) study [J] . Arschang Valipour, Felix JF Herth, Ralf Eberhardt, BMC Pulmonary Medicine . 2014,第1期

机译：具有上叶优势（STEP-UP）研究的肺气肿的随机对照分阶段治疗设计
2. Comparative Analysis of Group Sequential Designs Tests for Randomized Controlled Clinical Trials: A Model Study on Two-Sided Tests for Comparing Two Treatments [J] . Mehmet Ali Sungur, Emine Arzu Kanik Open Journal of Statistics . 2012,第1期

机译：随机对照临床试验的组顺序设计试验比较分析：比较两种治疗方法的双向试验模型研究
3. Rivaroxaban compared to no treatment in ER-negative stage I–III early breast cancer patients (the TIP Trial): study protocol for a phase II preoperative window-of-opportunity study design randomised controlled trial [J] . John Castle, Emma Blower, Nigel J. Bundred, Trials . 2020,第1期

机译：Rivaroxaban与ER阴性阶段I-III期早期乳腺癌患者（The Tip试验）的术语：研究议定书，适用于II期术前的机会研究设计随机对照试验
4. Surgical treatment of end-stage emphysema [C] . E. Cohen Postgraduate Course in Critical Care Medicine . 2003

机译：终级肺气肿外科治疗
5. Effect of acute lung volume reduction surgery on lung mechanics and maximal flow in a canine model of upper lobe emphysema. [D] . Buduhan, Gordon. 2005

机译：急性肺减容术对上肺气肿犬模型肺力学和最大流量的影响。
6. Transluminal endoscopic step-up approach versus minimally invasive surgical step-up approach in patients with infected necrotising pancreatitis (TENSION trial): design and rationale of a randomised controlled multicenter trial ISRCTN09186711 [O] . Sandra van Brunschot, Janneke van Grinsven, Rogier P Voermans, 2013

机译：感染性坏死性胰腺炎患者的腔内镜内升压与微创手术升压方法（TENSION试验）：一项随机对照多中心试验的设计和原理ISRCTN09186711
7. Design of the randomized, controlled sequential staged treatment of emphysema with upper lobe predominance (STEP-UP) study [O] . Arschang Valipour, Felix JF Herth, Ralf Eberhardt, 2014

机译：具有上叶优势（STEP-UP）研究的随机，受控序贯分期治疗肺气肿的设计

Design of the randomized controlled sequential staged treatment of emphysema with upper lobe predominance (STEP-UP) study

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