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首页> 美国卫生研究院文献>BMC Microbiology >Superoxide dismutase is upregulated in Staphylococcus aureus following protoporphyrin-mediated photodynamic inactivation and does not directly influence the response to photodynamic treatment
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Superoxide dismutase is upregulated in Staphylococcus aureus following protoporphyrin-mediated photodynamic inactivation and does not directly influence the response to photodynamic treatment

机译：原卟啉介导的光动力失活后金黄色葡萄球菌中的超氧化物歧化酶上调并且不直接影响对光动力治疗的反应

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BackgroundStaphylococcus aureus, a major human pathogen causes a wide range of disease syndromes. The most dangerous are methicillin-resistant S. aureus (MRSA) strains, resistant not only to all β-lactam antibiotics but also to other antimicrobials. An alarming increase in antibiotic resistance spreading among pathogenic bacteria inclines to search for alternative therapeutic options, for which resistance can not be developed easily. Among others, photodynamic inactivation (PDI) of S. aureus is a promising option. Photodynamic inactivation is based on a concept that a non toxic chemical, called a photosensitizer upon excitation with light of an appropriate wavelength is activated. As a consequence singlet oxygen and other reactive oxygen species (e.g. superoxide anion) are produced, which are responsible for the cytotoxic effect towards bacterial cells. As strain-dependence in photodynamic inactivation of S. aureus was observed, determination of the molecular marker(s) underlying the mechanism of the bacterial response to PDI treatment would be of great clinical importance. We examined the role of superoxide dismutases (Sod) in photodynamic inactivation of S. aureus as enzymes responsible for oxidative stress resistance.
机译：背景金黄色葡萄球菌是一种主要的人类病原体，可引起多种疾病综合征。最危险的是耐甲氧西林的金黄色葡萄球菌（MRSA），不仅对所有β-内酰胺类抗生素都有抵抗力，而且对其他抗菌素也有抵抗力。致病性细菌中抗生素耐药性扩散的惊人增加倾向于寻找替代的治疗选择，而对于这些治疗方法，耐药性不易发展。其中，金黄色葡萄球菌的光动力学灭活（PDI）是一种有前途的选择。光动力失活基于这样的概念：当用适当波长的光激发时，称为光敏剂的无毒化学物质被活化。结果产生了单线态氧和其他活性氧物质（例如超氧阴离子），其负责对细菌细胞的细胞毒性作用。由于观察到金黄色葡萄球菌的光动力学失活具有应变依赖性，因此确定细菌对PDI治疗的反应机理的分子标记具有重要的临床意义。我们检查了超氧化物歧化酶（Sod）在金黄色葡萄球菌的光动力学失活中的作用，作为负责氧化应激抗性的酶。

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