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Outcome disparities in African American women with triple negative breast cancer: a comparison of epidemiological and molecular factors between African American and Caucasian women with triple negative breast cancer

机译:非洲裔美国女性三重阴性乳腺癌的结果差异:非裔美国人和白人女性三重阴性乳腺癌的流行病学和分子因素比较

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摘要

BackgroundAlthough diagnosed less often, breast cancer in African American women (AAW) displays different characteristics compared to breast cancer in Caucasian women (CW), including earlier onset, less favorable clinical outcome, and an aggressive tumor phenotype. These disparities may be attributed to differences in socioeconomic factors such as access to health care, lifestyle, including increased frequency of obesity in AAW, and tumor biology, especially the higher frequency of triple negative breast cancer (TNBC) in young AAW. Improved understanding of the etiology and molecular characteristics of TNBC in AAW is critical to determining whether and how TNBC contributes to survival disparities in AAW.
机译:背景尽管尽管被诊断的频率较低,但非洲裔美国女性(AAW)的乳腺癌与白人女性(CW)的乳腺癌相比具有不同的特征,包括发病较早,临床效果较差以及侵袭性肿瘤表型。这些差异可能归因于社会经济因素的差异,例如获得医疗保健,生活方式,包括AAW中肥胖发生率增加,以及肿瘤生物学,尤其是年轻AAW中三阴性乳腺癌(TNBC)发生率更高。更好地了解AAW中TNBC的病因和分子特征对于确定TNBC是否以及如何导致AAW生存差异至关重要。

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