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首页> 外文期刊>BMC Cancer >Outcome disparities in African American women with triple negative breast cancer: a comparison of epidemiological and molecular factors between African American and Caucasian women with triple negative breast cancer
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Outcome disparities in African American women with triple negative breast cancer: a comparison of epidemiological and molecular factors between African American and Caucasian women with triple negative breast cancer

机译：非洲裔美国女性三重阴性乳腺癌的结果差异：非裔美国人和白人女性三重阴性乳腺癌的流行病学和分子因素比较

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Background Although diagnosed less often, breast cancer in African American women (AAW) displays different characteristics compared to breast cancer in Caucasian women (CW), including earlier onset, less favorable clinical outcome, and an aggressive tumor phenotype. These disparities may be attributed to differences in socioeconomic factors such as access to health care, lifestyle, including increased frequency of obesity in AAW, and tumor biology, especially the higher frequency of triple negative breast cancer (TNBC) in young AAW. Improved understanding of the etiology and molecular characteristics of TNBC in AAW is critical to determining whether and how TNBC contributes to survival disparities in AAW. Methods Demographic, pathological and survival data from AAW (n?=?62) and CW (n?=?98) with TNBC were analyzed using chi-square analysis, Student’s t-tests, and log-rank tests. Frozen tumor specimens were available from 57 of the TNBC patients (n?=?23 AAW; n?=?34 CW); RNA was isolated after laser microdissection of tumor cells and was hybridized to HG U133A 2.0 microarrays. Data were analyzed using ANOVA with FDR 2-fold difference defining significance. Results The frequency of TNBC compared to all BC was significantly higher in AAW (28%) compared to CW (12%), however, significant survival and pathological differences were not detected between populations. Gene expression analysis revealed the tumors were more similar than different at the molecular level, with only CRYBB2P1, a pseudogene, differentially expressed between populations. Among demographic characteristics, AAW consumed significantly lower amounts of caffeine and alcohol, were less likely to breastfeed and more likely to be obese. Conclusions These data suggest that TNBC in AAW is not a unique disease compared to TNBC in CW. Rather, higher frequency of TNBC in AAW may, in part, be attributable to the effects of lifestyle choices. Because these risk factors are modifiable, they provide new opportunities for the development of risk reduction strategies that may decrease mortality by preventing the development of TNBC in AAW.
机译：背景技术尽管非洲裔美国女性乳腺癌（AAW）的诊断率较低，但与白人女性（CW）的乳腺癌相比却表现出不同的特征，包括发病较早，临床效果较差以及侵袭性肿瘤表型。这些差异可能归因于社会经济因素的差异，例如获得医疗保健，生活方式（包括AAW中肥胖症的发生频率增加）和肿瘤生物学，尤其是年轻AAW中三阴性乳腺癌（TNBC）的发生频率较高。更好地了解AAW中TNBC的病因和分子特征对于确定TNBC是否以及如何导致AAW生存差异至关重要。方法使用卡方分析，Student's t检验和对数秩检验分析来自TNBC的AAW（n？=？62）和CW（n？=？98）的人口统计学，病理学和生存数据。冷冻肿瘤标本可从57例TNBC患者中获得（n？=？23 AAW; n？=？34 CW）。在对肿瘤细胞进行激光显微切割后，分离出RNA，并与HG U133A 2.0微阵列杂交。使用具有2倍FDR差异定义显着性的ANOVA分析数据。结果AAW（28％）的TNBC频率高于所有BC，而CW（12％）则显着更高，但是在人群之间未发现显着的存活率和病理学差异。基因表达分析显示，在分子水平上，肿瘤比相似的肿瘤多得多，只有假基因CRYBB2P1在人群之间表达差异。在人口统计学特征中，AAW消耗的咖啡因和酒精量明显较低，母乳喂养的可能性较小，肥胖的可能性更高。结论这些数据表明，AAW中的TNBC与CW中的TNBC相比并不是唯一的疾病。相反，AAW中TNBC的较高频率可能部分归因于生活方式选择的影响。由于这些风险因素是可修改的，因此它们为制定降低风险的策略提供了新的机会，这些策略可以通过防止AAW中TNBC的发展来降低死亡率。

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