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Algebraic correction methods for computational assessment of clone overlaps in DNA fingerprint mapping

机译：DNA指纹图谱中克隆重叠计算评估的代数校正方法

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BackgroundThe Sulston score is a well-established, though approximate metric for probabilistically evaluating postulated clone overlaps in DNA fingerprint mapping. It is known to systematically over-predict match probabilities by various orders of magnitude, depending upon project-specific parameters. Although the exact probability distribution is also available for the comparison problem, it is rather difficult to compute and cannot be used directly in most cases. A methodology providing both improved accuracy and computational economy is required.

机译：背景Sulston分数是一个公认的指标，尽管是用于概率评估DNA指纹图谱中假定的克隆重叠的近似指标。众所周知，根据项目特定的参数，系统会以各种数量级过高地预测匹配概率。尽管确切的概率分布也可用于比较问题，但它很难计算，在大多数情况下不能直接使用。需要一种既提供准确性又提供计算经济性的方法。

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期刊名称 BMC Bioinformatics
作者
Michael C Wendl;
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作者单位

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年(卷),期 2007(8),-1
年度 2007
页码 127
总页数 6
原文格式 PDF
正文语种
中图分类应用微生物学;生化遗传学;生化药理学;
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专利

1. Algebraic correction methods for computational assessment of clone overlaps in DNA fingerprint mapping [J] . Michael C Wendl BMC Bioinformatics . 2007,第1期

机译：DNA指纹图谱中克隆重叠计算评估的代数校正方法
2. Algebraic correction methods for computational assessment of clone overlaps in DNA fingerprint mapping [J] . Michael C Wendl BMC Bioinformatics . 2007,第1期

机译：DNA指纹图谱中克隆重叠计算评估的代数校正方法
3. Probabilistic assessment of clone overlaps in DNA fingerprint mapping via a priori models [J] . Wendl MC Journal of computational biology: A journal of computational molecular cell biology . 2005,第3期

机译：通过先验模型对DNA指纹图谱中克隆重叠进行概率评估
4. Detection of multiple overlapping bands of known amplitude, with application to DNA fingerprinting [C] . Fuhrmann, D.R. . 2002

机译：检测已知幅度的多个重叠谱带，并应用于DNA指纹图谱
5. Development of a map-based cloning system in Sorghum bicolor: 1. Isolation of megabase-size DNA and construction of a bacterial artificial chromosome library and 2. Genetic and physical mapping of the 5S rDNA locus. [D] . Woo, Sung-Sick. 1996

机译：双色高粱基于图谱的克隆系统的开发：1.分离碱基大小庞大的DNA和构建细菌人工染色体文库，以及2. 5S rDNA基因座的遗传和物理作图。
6. A general method for efficient non-isotopic labeling of DNA probes cloned in M13 vectors: application to DNA fingerprinting. [O] . A M Macedo, A C Medeiros, S D Pena 1989

机译：有效克隆M13载体中的DNA探针的有效非同位素标记的一般方法：应用于DNA指纹识别。
7. Algebraic correction methods for computational assessment of clone overlaps in DNA fingerprint mapping [O] . 2007

机译：DNA指纹图谱中克隆重叠计算评估的代数校正方法
8. Cloning-idependent mapping technology for genomic fidelity, contig linking, C-DNA site analysis, and gene detection. Final report [R] . Lerman, L. S. 1994

机译：用于基因组保真度，重叠群连接，C-DNa位点分析和基因检测的克隆依赖性绘图技术。总结报告

Algebraic correction methods for computational assessment of clone overlaps in DNA fingerprint mapping

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