• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>Biology >Transcriptional Regulation of the Mitochondrial Citrate and Carnitine/Acylcarnitine Transporters: Two Genes Involved in Fatty Acid Biosynthesis and β-oxidation
【2h】

Transcriptional Regulation of the Mitochondrial Citrate and Carnitine/Acylcarnitine Transporters: Two Genes Involved in Fatty Acid Biosynthesis and β-oxidation

机译：线粒体柠檬酸和肉碱/酰基肉碱转运蛋白的转录调控：两个基因参与脂肪酸的生物合成和β氧化。

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Transcriptional regulation of genes involved in fatty acid metabolism is considered the major long-term regulatory mechanism controlling lipid homeostasis. By means of this mechanism, transcription factors, nutrients, hormones and epigenetics control not only fatty acid metabolism, but also many metabolic pathways and cellular functions at the molecular level. The regulation of the expression of many genes at the level of their transcription has already been analyzed. This review focuses on the transcriptional control of two genes involved in fatty acid biosynthesis and oxidation: the citrate carrier (CIC) and the carnitine/ acylcarnitine/carrier (CAC), which are members of the mitochondrial carrier gene family, SLC25. The contribution of tissue-specific and less tissue-specific transcription factors in activating or repressing CIC and CAC gene expression is discussed. The interaction with drugs of some transcription factors, such as PPAR and FOXA1, and how this interaction can be an attractive therapeutic approach, has also been evaluated. Moreover, the mechanism by which the expression of the CIC and CAC genes is modulated by coordinated responses to hormonal and nutritional changes and to epigenetics is highlighted.
机译：参与脂肪酸代谢的基因的转录调控被认为是控制脂质稳态的主要长期调控机制。通过这种机制，转录因子，营养素，激素和表观遗传学不仅可以控制脂肪酸的代谢，而且可以在分子水平上控制许多代谢途径和细胞功能。已经分析了许多基因在其转录水平上的表达调控。这篇综述的重点是涉及脂肪酸生物合成和氧化的两个基因的转录控制：柠檬酸盐载体（CIC）和肉碱/酰基肉碱/载体（CAC），它们是线粒体载体基因家族SLC25的成员。讨论了组织特异性和较少组织特异性转录因子在激活或抑制CIC和CAC基因表达中的作用。还评估了与某些转录因子（例如PPAR和FOXA1）的药物之间的相互作用，以及这种相互作用如何成为一种有吸引力的治疗方法。此外，强调了通过对激素和营养变化以及对表观遗传学的协调反应来调节CIC和CAC基因表达的机制。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号