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The Optimal Extraction Parameters and Anti-Diabetic Activity of Flavonoids from Ipomoea Batatas Leaf

机译:番薯叶中黄酮的最佳提取工艺及抗糖尿病活性

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摘要

Extraction parameters of flavonoids from Ipomoea batatas leaf (FIBL) and anti-diabetic activity of FIBL on alloxan induced diabetic mice were studied. The optimal extraction parameters of FIBL were obtained by single factor test and orthogonal test, as follows: ethanol concentration 60 %, ratio of solvent to raw material 30, extraction temperature 75 ° and extraction time 1.5 h, while extraction yield of FIBL was 5.94 %. FIBL treatment (50, 100, and 150 mg/ kg body weight) for 28 days resulted in a significant decrease in the concentration of fasting blood glucose (FBG), total cholesterol (TC) and triglyceride (TG) in diabetes mellitus mice. Furthermore, FIBL significantly increased body weight (bw) and serum high-density lipoprotein cholesterol (HDL-c) level. The data demonstrated FIBL at the dose of 100 mg/kg bw exhibited the optimal effect. The above results suggest that FIBL can control blood glucose and modulate the metabolism of blood lipid in diabetes mellitus mice.
机译:研究了番薯叶中黄酮类化合物的提取参数和FIBL对四氧嘧啶致糖尿病小鼠的抗糖尿病活性。通过单因素试验和正交试验确定了FIBL的最佳提取参数,其乙醇浓度为60%,溶剂与原料的比为30,提取温度为75°,提取时间为1.5 h,而FIBL的提取率为5.94%。 。 FIBL处理(50、100和150 mg / kg体重)持续28天导致糖尿病小鼠的空腹血糖(FBG),总胆固醇(TC)和甘油三酸酯(TG)浓度显着降低。此外,FIBL显着增加了体重(bw)和血清高密度脂蛋白胆固醇(HDL-c)水平。数据表明剂量为100 mg / kg bw的FIBL表现出最佳效果。上述结果表明,FIBL可以控制糖尿病小鼠的血糖并调节血脂的代谢。

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