Pharmacokinetic Interactions between Valproic Acid and Lorazepam (PIVOtAL Study): A Review of Site-Specific Practices

机译：丙戊酸与劳拉西m之间的药代动力学相互作用（PIVOtAL研究）：针对特定部位的实践的综述

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摘要

BackgroundCoadministration of lorazepam and valproic acid is identified by tertiary references as causing a major drug interaction that requires therapy modification and dosage adjustments. The proposed mechanism involves inhibition of lorazepam glucuronidation via direct inhibition of uridine 5′-diphosphate-glucuronosyltransferase enzymes by valproic acid. However, the clinical significance of this interaction is unclear.

机译：背景劳拉西m和丙戊酸的共同给药被三级参考文献鉴定为引起主要药物相互作用，需要进行治疗调整和剂量调整。拟议的机制涉及通过丙戊酸直接抑制尿苷5'-二磷酸-葡萄糖醛酸转移酶来抑制劳拉西m的葡萄糖醛酸苷化作用。但是，这种相互作用的临床意义尚不清楚。

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期刊名称 The Canadian Journal of Hospital Pharmacy
作者
Joane Y Tang; Tony K L Kiang; Mary H H Ensom;
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作者单位

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年(卷),期 2017(70),3
年度 2017
页码 171–178
总页数 8
原文格式 PDF
正文语种
中图分类药学;
关键词
valproic acid lorazepam pharmacokinetics drug-drug interaction uridine 5′-diphosphate-glucuronosyltransferases;

机译：丙戊酸;劳拉西m;药代动力学;药物相互作用;尿苷5-二磷酸-葡萄糖醛酸转移酶;

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专利

1. Pharmacokinetic Interactions between Valproic Acid and Lorazepam (PIVOtAL Study): A Review of Site-Specific Practices [J] . Joane Y Tang, Tony K L Kiang, Mary H H Ensom The Canadian journal of hospital pharmacy. . 2017,第3期

机译：丙戊酸和洛拉齐泮之间的药代动力学相互作用（关键研究）：对网站特定实践的综述
2. Pharmacokinetic and pharmacodynamic interaction of lorazepam and valproic acid in relation to UGT2B7 genetic polymorphism in healthy subjects. [J] . Chung JY, Cho JY, Yu KS, Clinical Pharmacology and Therapeutics . 2008,第4期

机译：劳拉西m和丙戊酸的药代动力学和药效学相互作用与健康受试者中UGT2B7基因多态性的关系。
3. A rapid and simple HPLC–MS/MS method for the simultaneous quantification of valproic acid and its five metabolites in human plasma and application to study pharmacokinetic interaction in Chinese epilepsy patients [J] . Dingsheng Wen, Ziyi Chen, Chao Yang, Journal of Pharmaceutical and Biomedical Analysis: An International Journal on All Drug-Related Topics in Pharmaceutical, Biomedical and Clinical Analysis . 2018,第期

机译：一种快速和简单的HPLC-MS / MS方法，用于同时定量丙戊酸及其五种代谢物，在人血浆中的应用，以研究中国癫痫患者的药代动力学相互作用
4. An in-vitro controlled release study of valproic acid encapsulated in a titania ceramic matrix [C] . M. J. Uddin, D. Mondal, C. A. Morris, Annual meeting exposition of the Controlled Release Society . 2011

机译：封装在二氧化钛陶瓷基质中的丙戊酸的体外控释研究
5. Developmental changes in the ovine blood brain barrier and pharmacokinetics of valproic acid: A microdialysis study. [D] . Kwan, Eddie Wai-Kuen. 2005

机译：绵羊血脑屏障的发育变化和丙戊酸的药代动力学：微透析研究。
6. Moclobemide monotherapy vs. combined therapy with valproic acid or carbamazepine in depressive patients: a pharmacokinetic interaction study [O] . Anita Rakic Ignjatovic, Branislava Miljkovic, Dejan Todorovic, 2009

机译：莫洛贝胺单药疗法与丙戊酸或卡马西平联合治疗抑郁症患者的药代动力学相互作用研究
7. Pharmacokinetic Interactions between Valproic Acid and Lorazepam (PIVOtAL Study): A Review of Site-Specific Practices [O] . Joane Y Tang, Tony K L Kiang, Mary H H Ensom 2017

机译：丙戊酸和洛拉齐泮之间的药代动力学相互作用（关键研究）：对特定场地实践的综述

Pharmacokinetic Interactions between Valproic Acid and Lorazepam (PIVOtAL Study): A Review of Site-Specific Practices

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