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首页> 美国卫生研究院文献>International Journal of Molecular Sciences >The Effects of Spaceflight Factors on the Human Plasma Proteome Including Both Real Space Missions and Ground-Based Experiments
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The Effects of Spaceflight Factors on the Human Plasma Proteome Including Both Real Space Missions and Ground-Based Experiments

机译：航天因素对人体血浆蛋白质组的影响包括实际空间飞行任务和地面实验

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The aim of the study was to compare proteomic data on the effects of spaceflight factors on the human body, including both real space missions and ground-based experiments. LC–MS/MS-based proteomic analysis of blood plasma samples obtained from 13 cosmonauts before and after long-duration (169–199 days) missions on the International Space Station (ISS) and for five healthy men included in 21-day-long head-down bed rest (HDBR) and dry immersion experiments were performed. The semi-quantitative label-free analysis revealed significantly changed proteins: 19 proteins were significantly different on the first (+1) day after landing with respect to background levels; 44 proteins significantly changed during HDBR and 31 changed in the dry immersion experiment. Comparative analysis revealed nine common proteins (A1BG, A2M, SERPINA1, SERPINA3, SERPING1, SERPINC1, HP, CFB, TF), which changed their levels after landing, as well as in both ground-based experiments. Common processes, such as platelet degranulation, hemostasis, post-translational protein phosphorylation and processes of protein metabolism, indicate common pathogenesis in ground experiments and during spaceflight. Dissimilarity in the lists of significantly changed proteins could be explained by the differences in the dynamics of effective development in the ground-based experiments. Data are available via ProteomeXchange using the identifier PXD013305.
机译：这项研究的目的是比较蛋白质组学数据，了解航天因素对人体的影响，包括实际的太空飞行任务和地面实验。基于LC-MS / MS的蛋白质组学分析，分析了13位宇航员在国际空间站（ISS）进行的长时间飞行（169-199天）之前和之后以及21天之内包括的五名健康男性的血浆样品进行了平躺式卧床休息（HDBR）和干式浸泡实验。半定量无标记分析显示蛋白质发生了显着变化：19种蛋白质在降落后的第一（+1）天相对于背景水平有显着差异； HDBR过程中有44种蛋白质发生了显着变化，干浸实验中有31种发生了变化。对比分析显示了九种常见蛋白（A1BG，A2M，SERPINA1，SERPINA3，SERPING1，SERPINC1，HP，CFB，TF），它们在着陆后以及在两个基于地面的实验中均改变了它们的水平。常见过程，例如血小板脱粒，止血，翻译后蛋白磷酸化和蛋白代谢过程，表明了地面实验和太空飞行中的常见发病机理。显着变化的蛋白质列表中的差异可以通过基于地面的实验中有效开发的动力学差异来解释。可以通过ProteomeXchange使用标识符PXD013305获得数据。

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