Cyclo-Oxygenase (COX) Inhibitors and Cardiovascular Risk: Are Non-Steroidal Anti-Inflammatory Drugs Really Anti-Inflammatory?

机译：环氧合酶抑制剂和心血管风险：非甾体类抗炎药是否真的具有抗炎作用？

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Cyclo-oxygenase (COX) inhibitors are among the most commonly used drugs in the western world for their anti-inflammatory and analgesic effects. However, they are also well-known to increase the risk of coronary events. This area is of renewed significance given alarming new evidence suggesting this effect can occur even with acute usage. This contrasts with the well-established usage of aspirin as a mainstay for cardiovascular prophylaxis, as well as overwhelming evidence that COX inhibition induces vasodilation and is protective for vascular function. Here, we present an updated review of the preclinical and clinical literature regarding the cardiotoxicity of COX inhibitors. While studies to date have focussed on the role of COX in influencing renal and vascular function, we suggest an interaction between prostanoids and T cells may be a novel factor, mediating elevated cardiovascular disease risk with NSAID use.

机译：环氧合酶（COX）抑制剂具有抗炎和镇痛作用，是西方世界最常用的药物之一。但是，众所周知，它们会增加冠状动脉事件的风险。鉴于令人震惊的新证据表明，即使急性使用也可能发生这种作用，这一领域具有新的意义。与之形成鲜明对比的是，阿司匹林已被广泛用作心血管疾病预防的主要手段，同时也有大量证据表明，COX抑制可引起血管舒张并保护血管功能。在这里，我们介绍了有关COX抑制剂心脏毒性的临床前和临床文献的最新综述。尽管迄今为止的研究都集中在COX在影响肾脏和血管功能中的作用，但我们建议前列腺素和T细胞之间的相互作用可能是一个新因素，可通过使用NSAID介导心血管疾病的风险升高。

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期刊名称 International Journal of Molecular Sciences
作者
Shanzana Khan; Karen L. Andrews; Jaye P. F. Chin-Dusting;
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作者单位

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年(卷),期 2019(20),17
年度 2019
页码 4262
总页数 18
原文格式 PDF
正文语种
中图分类分子生物学;
关键词
cyclo-oxygenase prostanoids T cells immune-mediated hypertension adaptive immunity vascular dysfunction coronary disease;

机译：环氧合酶;前列腺素;T细胞;免疫介导的高血压;适应性免疫;血管功能障碍;冠心病;

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专利

1. Use of cyclo-oxygenase 2 inhibitors (COX-2) and prescription non-steroidal anti-inflammatory drugs (NSAIDS) in UK and USA populations. Implications for COX-2 cardiovascular profile. [J] . Arellano FM, Yood MU, Wentworth CE, Pharmacoepidemiology and drug safety . 2006,第12期

机译：在英国和美国人群中使用环加氧酶2抑制剂（COX-2）和处方非甾体类抗炎药（NSAIDS）。对COX-2心血管特征的影响。
2. Are COX-2 inhibitors preferable to non-selective non-steroidal anti-inflammatory drugs in patients with risk of cardiovascular events taking low-dose aspirin? [J] . Strand V The Lancet . 2007,第9605期

机译：对于服用小剂量阿司匹林有心血管事件风险的患者，COX-2抑制剂优于非选择性非甾体类抗炎药吗？
3. COX-2 selectivity alone does not define the cardiovascular risks associated with non-steroidal anti-inflammatory drugs. [J] . Warner TD, Mitchell JA The Lancet . 2008,第9608期

机译：单独的COX-2选择性并不能确定与非甾体类抗炎药有关的心血管风险。
4. Investigating risk factors associated with passive immunity, health, and growth and the effects of administering non-steroidal anti-inflammatory drug to beef calves assisted at birth [C] . Annual Conference of The American Association of Bovine Practitioners . 2018

机译：调查与被动免疫，健康和生长相关的风险因素以及将非甾体类抗炎药与出生辅助的牛肉小牛施用的影响
5. The relationship between non-steroidal anti-inflammatory drug prescription and the prescription of cardiovascular medications and prevalence of cardiovascular diseases among senior Albertans. [D] . Schaefer, Jeffrey Paul. 1999

机译：非甾体类抗炎药处方与心血管药物处方之间的关系以及艾伯塔省老年人的心血管疾病患病率。
6. Non-steroidal anti-inflammatory drugs: overall risks and management. Complementary roles for COX-2 inhibitors and proton pump inhibitors [O] . C J Hawkey, M J S Langman 2003

机译：非甾体类抗炎药：总体风险和管理。 COX-2抑制剂和质子泵抑制剂的互补作用
7. Re: use of cyclo-oxygenase 2 inhibitors (COX-2) and prescription non-steroidal anti-inflammatory drugs(NSAIDS) in UK and USA populations: implications for COX-2 cardiovascular profile [O] . van Staa, T.P., Parkinson, J. 2007

机译：回复：在英国和美国人群中使用环氧化酶2抑制剂（COX-2）和处方非甾体抗炎药（NsaIDs）：对COX-2心血管特征的影响

Cyclo-Oxygenase (COX) Inhibitors and Cardiovascular Risk: Are Non-Steroidal Anti-Inflammatory Drugs Really Anti-Inflammatory?

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