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首页> 美国卫生研究院文献>Journal of Neuroinflammation >Function and mechanism of toll-like receptors in cerebral ischemic tolerance: from preconditioning to treatment
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Function and mechanism of toll-like receptors in cerebral ischemic tolerance: from preconditioning to treatment

机译：Toll样受体在脑缺血耐受中的功能和机制：从预处理到治疗

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Increasing evidence suggests that toll-like receptors (TLRs) play an important role in cerebral ischemia-reperfusion injury. The endogenous ligands released from ischemic neurons activate the TLR signaling pathway, resulting in the production of a large number of inflammatory cytokines, thereby causing secondary inflammation damage following cerebral ischemia. However, the preconditioning for minor cerebral ischemia or the preconditioning with TLR ligands can reduce cerebral ischemic injury by regulating the TLR signaling pathway following ischemia in brain tissue (mainly, the inhibition of the TLR4/NF-κB signaling pathway and the enhancement of the interferon regulatory factor-dependent signaling), resulting in TLR ischemic tolerance. Additionally, recent studies found that postconditioning with TLR ligands after cerebral ischemia can also reduce ischemic damage through the regulation of the TLR signaling pathway, showing a significant therapeutic effect against cerebral ischemia. These studies suggest that the ischemic tolerance mediated by TLRs can serve as an important target for the prevention and treatment of cerebral ischemia. On the basis of describing the function and mechanism of TLRs in mediating cerebral ischemic damage, this review focuses on the mechanisms of cerebral ischemic tolerance induced by the preconditioning and postconditioning of TLRs and discusses the clinical application of TLRs for ischemic tolerance.
机译：越来越多的证据表明，toll​​样受体（TLR）在脑缺血再灌注损伤中起重要作用。从局部缺血神经元释放的内源性配体激活TLR信号通路，导致大量炎症细胞因子的产生，从而在脑缺血后引起继发性炎症损害。但是，对小脑缺血的预处理或TLR配体的预处理可以通过调节脑组织缺血后的TLR信号通路来减少脑缺血损伤（主要是抑制TLR4 /NF-κB信号通路和增强干扰素）。调节因子依赖性信号传导），导致TLR缺血耐受。此外，最近的研究发现，在脑缺血后用TLR配体进行后处理还可以通过调节TLR信号通路来减少缺血损伤，显示出对脑缺血的显着治疗效果。这些研究表明，TLR介导的缺血耐受可以作为预防和治疗脑缺血的重要靶标。在描述TLRs介导脑缺血损伤的功能和机制的基础上，本文综述了TLRs预处理和后处理引起的脑缺血耐受的机制，并探讨了TLRs在缺血耐受中的临床应用。

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