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首页> 美国卫生研究院文献>Journal of Korean Medical Science >Clinical Effectiveness of Urinary Human Chorionic Gonadotropin Related Protein (hCGRP) Quantification for Diagnosis of Ectopic Pregnancy
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Clinical Effectiveness of Urinary Human Chorionic Gonadotropin Related Protein (hCGRP) Quantification for Diagnosis of Ectopic Pregnancy

机译：尿人绒毛膜促性腺激素相关蛋白（hCGRP）定量在异位妊娠诊断中的临床效果

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We detected pregnancy related new molecule, human chorionic gonadotropin related protein (hCGRP) in the urine of a pregnant women by using a monoclonal antibody against the human chorionic gonadotropin (hCG). This study examined the effectiveness of urinary hCGRP quantification in diagnosing ectopic pregnancy. This study included 40 normal pregnant women and 25 patients with ectopic pregnancy. Patients' serum and urinary intact whole hCG (i-hCG) and hCGRP concentrations were measured using sandwich ELISA and the ratio of hCGRP to i-hCG was calculated. Statistical analysis was performed using statistical package for social sciences (SPSS) 10.0. Receiver operating characteristic (ROC) curve analysis was performed to evaluate the cut-off value to discriminate ectopic pregnancies from normal intrauterine pregnancies. Urinary hCGRP and hCGRP/i-hCG ratio in ectopic pregnancy group (14±6.6 ng/mL, 4.6±1.9%, respectively) were significantly lower than those of normal pregnancy group (149±10.2 ng/mL, 29.7±1.9%, respectively; p<0.001). Based on ROC curve analysis, a cut-off point of urinary hCGRP/i-hCG ratio <16.2% discriminated between ectopic pregnancy and normal pregnancy with a sensitivity, specificity, positive predictive value and negative predictive value of 92.0%, 90.0%, 32.6%, and 99.5%, respectively. Urinary hCGRP/i-hCG ratio measurement may be effective in diagnosing ectopic pregnancy.
机译：我们通过使用针对人绒毛膜促性腺激素（hCG）的单克隆抗体，在孕妇的尿液中检测到了与妊娠相关的新分子，人绒毛膜促性腺激素相关蛋白（hCGRP）。这项研究检查了尿hCGRP定量在异位妊娠诊断中的有效性。该研究包括40名正常孕妇和25名异位妊娠患者。使用夹心ELISA测定患者的血清和尿液完整hCG（i-hCG）和hCGRP浓度，并计算hCGRP与i-hCG的比率。使用社会科学统计软件包（SPSS）10.0进行统计分析。进行受试者工作特征（ROC）曲线分析以评估临界值，以将异位妊娠与正常宫内妊娠区分开。异位妊娠组的尿hCGRP和hCGRP / i-hCG比率（分别为14±6.6 ng / mL，4.6±1.9％）显着低于正常妊娠组（149±10.2 ng / mL，29.7±1.9％），分别为p <0.001）。根据ROC曲线分析，异位妊娠与正常妊娠的尿hCGRP / i-hCG临界值<16.2％区分为敏感性，特异性，阳性预测值和阴性预测值分别为92.0％，90.0％，32.6 ％和99.5％。尿hCGRP / i-hCG比值的测定可能对诊断异位妊娠有效。

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