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Signaling responses to high and moderate load strength exercise in trained muscle

机译:对受过训练的肌肉中高中度负荷强度运动的信号反应

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摘要

We examined signaling responses in the skeletal muscle of strength athletes after strength exercises under high and moderate load. Eight trained male powerlifters were recruited. The volunteers performed four sets of leg presses to volitional fatigue using a moderate load (65% 1‐repetition maximum [1RM]) for one leg, and a high load (85% 1RM) for the contralateral leg. The work volume performed by the leg moving a moderate load was higher than that of the contralateral leg moving a high load. Biopsy of the m. vastus lateralis was performed before, and at 1, 5, and 10 h after, cessation of exercise. Phosphorylation of p70S6kThr389, 4E‐BP1Thr37/46, and ACCS er79 increased after moderate load exercises, whereas phosphorylation of ERK1/2Thr202/Tyr204 increased, and that of eEF2Thr56 decreased, after high load exercises. Exercise under a moderate load and a high work volume activated mTORC1‐dependent signaling in trained skeletal muscle, whereas exercise under a high load but lower work volume activated the MEK‐ERK1/2 signaling cascade and eEF2.
机译:我们检查了高强度和中等强度的力量运动后力量运动员骨骼肌的信号传导反应。招募了八名训练有素的男性举重运动员。志愿者对四只腿进行压腿训练,以使一只腿承受中等程度的负荷(65%1次重复最大[1RM]),而对侧腿承受高负荷(85%1RM)。腿部承受中等负荷时的工作量要大于对侧腿部承受高负荷时的工作量。 m的活检。在停止运动之前,之后1、5和10 h进行股外侧肌。中等负荷运动后,p70S6k Thr389 ,4E-BP1 Thr37 / 46 和ACC S er79 的磷酸化增加,高负荷运动后,ERK1 / 2 Thr202 / Tyr204 的磷酸化增加,而eEF2 Thr56 的磷酸化减少。在中等负荷和高工作量下进行锻炼会激活受过训练的骨骼肌中mTORC1依赖的信号传导,而在高负荷但较低工作量下进行锻炼会激活MEK-ERK1 / 2信号级联和eEF2。

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