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首页> 外文期刊>Physiological Reports >Signaling responses to high and moderate load strength exercise in trained muscle
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Signaling responses to high and moderate load strength exercise in trained muscle

机译：对受过训练的肌肉中高中度负荷强度运动的信号反应

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摘要

We examined signaling responses in the skeletal muscle of strength athletes after strength exercises under high and moderate load. Eight trained male powerlifters were recruited. The volunteers performed four sets of leg presses to volitional fatigue using a moderate load (65% 1‐repetition maximum [1RM]) for one leg, and a high load (85% 1RM) for the contralateral leg. The work volume performed by the leg moving a moderate load was higher than that of the contralateral leg moving a high load. Biopsy of the m .? vastus lateralis was performed before, and at 1, 5, and 10?h after, cessation of exercise. Phosphorylation of p70S6k Thr389 , 4E‐BP1 Thr37/46 , and ACC S er79 increased after moderate load exercises, whereas phosphorylation of ERK1/2 Thr202/Tyr204 increased, and that of eEF2 Thr56 decreased, after high load exercises. Exercise under a moderate load and a high work volume activated mTORC1‐dependent signaling in trained skeletal muscle, whereas exercise under a high load but lower work volume activated the MEK‐ERK1/2 signaling cascade and eEF2.
机译：我们检查了高强度和中等强度的力量运动后力量运动员骨骼肌中的信号传导反应。招募了八名训练有素的男性举重运动员。志愿者对四只腿施加压力，以使腿部疲劳，其中一只腿承受中等负荷（最大重复次数[65％1次重复[1RM]），对侧腿承受高负荷（85％1RM）。在中等负荷下移动腿的工作量要比在高负荷下对侧腿进行的工作量大。 m的活检。在停止运动之前，之后1、5和10？h进行了外侧股阔肌。中等负荷运动后，p70S6k Thr389、4E-BP1 Thr37 / 46和ACC S er79的磷酸化增加，而高负荷运动后，ERK1 / 2 Thr202 / Tyr204的磷酸化增加，而eEF2 Thr56的磷酸化降低。在中等负荷和高工作量下进行锻炼会激活受过训练的骨骼肌中mTORC1依赖性信号传导，而在高负荷但较低工作量下进行锻炼会激活MEK-ERK1 / 2信号级联和eEF2。

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