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Dietary minerals reproductive hormone levels and sporadic anovulation: associations in healthy women with regular menstrual cycles

机译：膳食矿物质生殖激素水平和散发性无排卵：健康女性的月经周期规律

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Although minerals are linked to several reproductive outcomes, it is unknown whether dietary minerals are associated with ovulatory function. We hypothesized that low intakes of minerals would be associated with an increased risk of anovulation. We investigated associations between dietary mineral intake and both reproductive hormones and anovulation in healthy women in the BioCycle Study, which prospectively followed 259 regularly menstruating women, aged 18–44 years who were not taking mineral supplements for 2 menstrual cycles. Intakes of 10 selected minerals were assessed via 24-hour dietary recalls at up to 4 times per cycle in each participant. Estradiol, progesterone, luteinizing hormone (LH), follicle-stimulating hormone (FSH), sex hormone-binding globulin, and testosterone were measured in serum up to 8 times per cycle. We used weighted linear mixed models to evaluate associations between minerals and hormones and generalized linear models for risk of anovulation. Compared to sodium intake ≥1,500mg, sodium intake <1,500mg was associated with higher levels of FSH (21.3%, 95% CI 7.5, 36.9), LH (36.8%, 95% CI 16.5, 60.5), and lower progesterone (−36.9%, 95% CI −56.5, −8.5). Sodium intake <1,500mg (risk ratio [RR] 2.70, 95% confidence interval [CI] 1.00, 7.31) and manganese intake <1.8mg (RR 2.00, 95% CI 1.02, 3.94) were associated with an increased risk of anovulation, compared to higher intakes respectively. Other measured dietary minerals were not associated with ovulatory function. As essential minerals are mostly obtained via diet, our results comparing insufficient to sufficient levels highlight the need for future research on dietary nutrients and their associations with ovulatory cycles.
机译：尽管矿物质与几种生殖结果有关，但尚不清楚饮食矿物质是否与排卵功能有关。我们假设矿物质摄入量低会导致无排卵的风险增加。在《生物周期研究》中，我们调查了健康女性的饮食中矿物质摄入与生殖激素和无排卵之间的关系，该研究预期随访了259名年龄在18-44岁之间的月经正常妇女，她们在两个月经周期中均未服用矿物质补充剂。通过24小时饮食召回来评估10种选定矿物质的摄入量，每个参与者每个周期最多进行4次。在每个周期中最多测量8次血清中的雌二醇，孕酮，黄体生成激素（LH），促卵泡激素（FSH），性激素结合球蛋白和睾丸激素。我们使用加权线性混合模型来评估矿物质和激素之间的关联，并使用广义线性模型来评估无排卵的风险。与钠摄入量≥1,500mg相比，钠摄入量<1,500mg与较高水平的FSH（21.3％，95％CI 7.5，36.9），LH（36.8％，95％CI 16.5，60.5）和较低的孕激素水平相关- 36.9％，95％CI -56.5，-8.5）。摄入钠<1,500mg（风险比[RR] 2.70，95％置信区间[CI] 1.00，7.31）和锰摄入<1.8mg（RR 2.00，95％CI 1.02，3.94）与无排卵风险增加相关，与更高的摄入量相比。其他测定的饮食矿物质与排卵功能无关。由于必需矿物质大部分是通过饮食获得的，因此我们比较不足和足够水平的结果表明，有必要进一步研究饮食营养及其与排卵周期的关系。

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