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首页> 美国卫生研究院文献>other >Relationship between Inter-arm Difference in Systolic Blood Pressure and Arterial Stiffness in Community-dwelling Older Adults
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Relationship between Inter-arm Difference in Systolic Blood Pressure and Arterial Stiffness in Community-dwelling Older Adults

机译：社区居民老年人手臂间收缩压差异与动脉僵硬度之间的关系

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A significant inter-arm difference in systolic blood pressure (IADSBP) has been recently associated with worse cardiovascular outcomes. We hypothesized that part of this association is mediated by arterial stiffness, and examined the relationship between significant IADSBP and carotid-femoral pulse wave velocity (CF-PWV) in a sample from the Baltimore Longitudinal Study of Aging. Of 1045 participants, 50 (4.8%) had an IADSBP≥10 mmHg at baseline, and 629 had completed data from two or more visits (for a total of 1704 visits across 8 years). CF-PWV was significantly higher in those with an IADSBP≥10 mmHg (7.3±1.9 vs. 8.2±2, p=0.002). Compared to others, those with IADSBP≥10 mmHg had also higher body mass index, waist circumference and triglycerides, higher prevalence of diabetes and lower HDL-cholesterol (p<.001 for all). A significant association with IADSBP≥10 mmHg was observed for CF-PWV in both cross-sectional (OR=1.19; 95%CI: 1.06–1.87; p=0.01) and longitudinal (OR=1.15; 95%CI: 1.03–1.29; p=0.01) multivariate analyses. Female gender, Caucasian race, high body mass index (plus diabetes and low HDL-cholesterol only cross-sectionally) were other independent correlates of IADSBP≥10 mmHg. In conclusion, significant IADSBP is associated with increased arterial stiffness in community-dwelling older adults.
机译：最近，手臂间收缩压（IADSBP）的显着差异与心血管转归恶化有关。我们假设这种关联的一部分是由动脉僵硬度介导的，并研究了巴尔的摩纵向衰老研究的样本中显着的IADSBP与颈股股动脉脉搏波速度（CF-PWV）之间的关系。在1045名参与者中，有50名（4.8％）的基线IADSBP≥10 mmHg，有629名完成了两次或两次以上就诊的数据（8年中总共1704次就诊）。 IADSBP≥10mmHg的患者的CF-PWV明显更高（7.3±1.9对8.2±2，p = 0.002）。与其他人相比，IADSBP≥10mmHg的人还具有更高的体重指数，腰围和甘油三酸酯，更高的糖尿病患病率和更低的HDL-胆固醇（总体p <.001）。 CF-PWV的横截面（OR = 1.19； 95％CI：1.06-1.87； p = 0.01）和纵向（OR = 1.15； 95％CI：1.03-1.29）均与IADSBP≥10mmHg显着相关。 ; p = 0.01）多元分析。 IADSBP≥10mmHg的其他独立因素是女性，白人，高体重指数（加上糖尿病和低水平的HDL-胆固醇）。总之，在社区居住的老年人中，明显的IADSBP与动脉僵硬度增加有关。

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