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首页> 美国卫生研究院文献>Journal of Clinical Microbiology >Typhoid Fever Associated with Acute Appendicitis Caused by an H1-j Strain of Salmonella enterica Serotype Typhi
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Typhoid Fever Associated with Acute Appendicitis Caused by an H1-j Strain of Salmonella enterica Serotype Typhi

机译：肠炎沙门氏菌血清型伤寒H1-j株引起的与急性阑尾炎相关的伤寒

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摘要

While most strains of Salmonella enterica serotype Typhi, the etiologic agent of typhoid fever, have only a phase 1 flagellar antigen, H1-d, variations of the flagellar antigen have been observed. Although H1-j strains (one of the flagellar antigen variants) account for 10 to 50% of S. enterica serotype Typhi strains found in Indonesia, there have been no published data to suggest its existence in other parts of the world. We describe a case of typhoid fever associated with acute appendicitis caused by an S. enterica serotype Typhi H1-j strain in a Chinese woman in Hong Kong. A gram-negative, motile rod was recovered from her blood and stool cultures. Conventional biochemical tests and the Vitek system (GNI+) showed that the bacterium was S. enterica serotype Typhi. The isolate agglutinated with poly(O), 9O, Vi and H1-j Salmonella antisera but not with poly(H) antisera. The patient developed antibodies against only S. enterica serotype Typhi O antigens but not against H1-d antigen by the Widal test. Flagellin C gene (fliC) sequencing showed a 261-bp deletion in the fliC gene of the isolate, confirming that the isolate possessed the H1-j antigen. The patient had no past history of travel to Indonesia or personal contact with any Indonesian. She recovered with appendectomy and antibiotic treatment. Further studies should be performed to determine the prevalence of this unusual S. enterica serotype Typhi strain in our locality.
机译：尽管伤寒的病原体肠炎沙门氏菌血清型Typhi菌株仅具有1期鞭毛抗原H1-d，但已观察到鞭毛抗原的变异。尽管H1-j菌株（鞭毛抗原变体之一）占印度尼西亚发现的肠炎链球菌血清型鼠伤寒菌株的10％至5​​0％，但尚无公开数据表明其在世界其他地区的存在。我们描述了在香港一名中国妇女中，由肠炎沙门氏菌血清型Typhi H1-j株引起的与急性阑尾炎相关的伤寒的病例。从她的血液和粪便培养物中回收到了革兰氏阴性的活动杆。常规生化测试和Vitek系统（GNI +）表明，该细菌为肠炎链球菌血清型Typhi。分离株与poly（O），9O，Vi和H1-j沙门氏菌抗血清凝集，但未与poly（H）抗血清凝集。通过Widal试验，患者仅产生针对肠炎链球菌血清型鼠伤寒O抗原的抗体，而未针对H1-d抗原。鞭毛蛋白C基因（fliC）测序显示分离物的fliC基因缺失261 bp，证实该分离物具有H1-j抗原。该患者没有去印度尼西亚旅行的历史，也没有与任何印度尼西亚人的私人接触。她接受阑尾切除术和抗生素治疗后康复。应该进行进一步的研究以确定这种不寻常的肠炎链球菌血清型伤寒菌株在我们当地的流行程度。

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