首页> 外文期刊>Annals of Tropical Paediatrics >Bacteraemia with pleural effusions complicating typhoid fever caused by high-level ciprofloxacin-resistant Salmonella enterica serotype Typhi.
【24h】

Bacteraemia with pleural effusions complicating typhoid fever caused by high-level ciprofloxacin-resistant Salmonella enterica serotype Typhi.

机译:高水平耐环丙沙星肠炎沙门氏菌血清型伤寒引起的伤寒伴有胸水的细菌性发热。

获取原文
获取原文并翻译 | 示例
           

摘要

An unusual case of bacteraemia with bilateral pleural effusion caused by Salmonella enterica serotype Typhi in a 10-year-old previously healthy girl is reported. The organism was isolated from pleural fluid aspirate and from blood, and exhibited high-level ciprofloxacin resistance (MIC 16 mug/ml) associated with triple mutations in the QRDRs of the gyrA and parC genes leading to the amino-acid changes Ser83-->Phe and Asp87-->Asn in gyrA and Ser80-->Ile in parC. The patient was successfully treated with parenteral ceftriaxone and intercostal chest tube drainage. The case is notable because of the important issue of antimicrobial resistance in S. Typhi and the therapeutic dilemma faced by clinicians regarding the empirical use of ciprofloxacin and newer fluoroquinolones.
机译:据报道,在一个10岁以前健康的女孩中,由肠炎沙门氏菌血清型鼠伤寒引起的双侧胸腔积液菌血症异常病例。该微生物是从胸膜穿刺液和血液中分离出来的,并表现出高环丙沙星抗性(MIC 16 mug / ml),与gyrA和parC基因QRDR的三重突变相关,导致氨基酸改变Ser83-> Pyr和Asp87-> gyrA中的Asn和parC中的Ser80-> Ile。该患者经肠胃外头孢曲松和肋间胸管引流术成功治疗。该病例之所以引人注目,是因为伤寒沙门氏菌具有重要的抗药性问题,并且临床医生在经验上使用环丙沙星和新型氟喹诺酮类药物也面临着治疗难题。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号