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首页> 美国卫生研究院文献>International Journal of Molecular Sciences >Protective Effect of Ocotillol the Derivate of Ocotillol-Type Saponins in Panax Genus against Acetic Acid-Induced Gastric Ulcer in Rats Based on Untargeted Metabolomics
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Protective Effect of Ocotillol the Derivate of Ocotillol-Type Saponins in Panax Genus against Acetic Acid-Induced Gastric Ulcer in Rats Based on Untargeted Metabolomics

机译：基于非靶向代谢组学的人参皂苷类衍生物-蜡烛木皂苷的衍生物-蜡烛木对大鼠乙酸诱导的胃溃疡的保护作用

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摘要

Gastric ulcer (GU), a prevalent digestive disease, has a high incidence and is seriously harmful to human health. Finding a natural drug with a gastroprotective effect is needed. Ocotillol, the derivate of ocotillol-type saponins in the genus, possesses good anti-inflammatory activity. The study aimed to investigate the gastroprotective effect of ocotillol on acetic acid-induced GU rats. The serum levels of endothelin-1 (ET-1) and nitric oxide (NO), the gastric mucosa levels of epidermal growth factor, superoxide dismutase and NO were assessed. Hematoxylin and eosin staining of gastric mucosa for pathological changes and immunohistochemical staining of ET-1, epidermal growth factor receptors and inducible nitric oxide synthase were evaluated. A UPLC-QTOF-MS-based serum metabolomics approach was applied to explore the latent mechanism. A total of 21 potential metabolites involved in 7 metabolic pathways were identified. The study helps us to understand the pathogenesis of GU and to provide a potential natural anti-ulcer agent.
机译：胃溃疡（GU）是一种普遍的消化系统疾病，发病率很高，严重危害人体健康。需要找到具有胃肠保护作用的天然药物。 Ocotillol是该属中Ocotillol型皂苷的衍生物，具有良好的抗炎活性。该研究旨在研究奥古洛尔对乙酸诱导的GU大鼠的胃保护作用。评估血清内皮素-1（ET-1）和一氧化氮（NO）水平，胃粘膜表皮生长因子水平，超氧化物歧化酶和一氧化氮。评估胃粘膜苏木精和曙红的病理变化，并对ET-1，表皮生长因子受体和诱导型一氧化氮合酶进行免疫组织化学染色。基于UPLC-QTOF-MS的血清代谢组学方法被用于探索潜在的机制。共鉴定了涉及7种代谢途径的21种潜在代谢物。这项研究有助于我们了解GU的发病机理，并提供潜在的天然抗溃疡药。

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