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首页> 美国卫生研究院文献>Revista do Instituto de Medicina Tropical de So Paulo >Novel kidney injury biomarkers in tropical infections: a review ofthe literature
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Novel kidney injury biomarkers in tropical infections: a review ofthe literature

机译：新型肾脏损伤生物标志物在热带感染中的应用文献

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Tropical diseases are mainly found in the tropical regions of Asia, Africa andLatin America. They are a major Public Health problem in these regions, most ofthem are considered neglected diseases and remain as important contributors tothe development of AKI (Acute Kidney Injury), which is associated with increasedpatients’ morbidity and mortality. In most countries, kidney disease associatedto tropical diseases is attended at health services with poor infrastructure andinadequate preventive measures. The long-term impacts of these infections onkidney tissue may be a main cause of future kidney disease in these patients.Therefore, the investigation of novel kidney injury biomarkers in these tropicaldiseases is of utmost importance to explain the mechanisms of kidney injury, toimprove their diagnosis and prognosis, as well as the assessment to healthsystems by these patients. Since 2011, our group has been studying renalbiomarkers in visceral and cutaneous leishmaniasis, schistosomiasis,leptospirosis and leprosy. This study has increased the knowledge on thepathophysiology of kidney disease in the presence of these infections and hascontributed to the early diagnosis of kidney injury, pointing to glomerular,endothelial and inflammatory involvement as the main causes of the mechanismsleading to nephropathy and clinical complications. Future perspectives compriseestablishing long-term cohort groups to assess the development of kidney diseaseand the patients’ survival, as well as the use of new biomarkers such as urinaryexosomes to detect risk groups and to understand the progression of kidneyinjuries.
机译：热带疾病主要见于亚洲，非洲和非洲的热带地区。拉丁美洲。它们是这些地区的主要公共卫生问题，大部分它们被认为是被忽视的疾病，并且仍然是造成这些疾病的重要因素AKI（急性肾损伤）的发展，与患者的发病率和死亡率。在大多数国家，与肾脏疾病相关的基础设施薄弱，预防措施不足。这些感染的长期影响肾脏组织可能是这些患者未来肾脏疾病的主要原因。因此，在这些热带地区研究新型肾脏损伤生物标志物疾病对于解释肾脏损伤的机制至关重要，改善他们的诊断和预后以及对健康的评估这些患者使用的系统。自2011年以来，我们小组一直在研究肾脏内脏和皮肤利什曼病，血吸虫病，钩端螺旋体病和麻风病。这项研究增加了对存在这些感染的肾脏疾病的病理生理学和有助于肾损伤的早期诊断，指向肾小球，内皮和炎症受累是该机制的主要原因导致肾病和临床并发症。未来的观点包括建立长期的队列研究小组以评估肾脏疾病的发展以及患者的生存率，以及使用新的生物标记物（例如尿液）外泌体可检测危险人群并了解肾脏的进展受伤。

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