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Trimethoprim and other nonclassical antifolates an excellent template for searching modifications of dihydrofolate reductase enzyme inhibitors

机译：甲氧苄啶和其他非经典抗叶酸剂是寻找二氢叶酸还原酶抑制剂的修饰剂的出色模板

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期刊名称 Nature Public Health Emergency Collection
作者
Agnieszka Wróbel; Karolina Arciszewska; Dawid Maliszewski; Danuta Drozdowska;
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作者单位

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年(卷),期 -1(73),1
年度 -1
页码 -1
总页数 23
原文格式 PDF
正文语种
中图分类精神病学;
关键词
Drug development; Antibiotics; Antibiotics; Drug development; Antibiotics;

机译：药物开发;抗生素;抗生素;药物开发;抗生素;

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专利

1. Trimethoprim and other nonclassical antifolates an excellent template for searching modifications of dihydrofolate reductase enzyme inhibitors [J] . Wrobel Agnieszka, Arciszewska Karolina, Maliszewski Dawid, The Journal of Antibiotics: An International Journal . 2020,第1期

机译：Trimethokim和其他非化学防雾的优异模板，用于搜索二氢脱水还原酶酶抑制剂的改性
2. The effect of 5-alkyl modification on the biological activity of pyrrolo[2,3-d]pyrimidine containing classical and nonclassical antifolates as inhibitors of dihydrofolate reductase and as antitumor and/or antiopportunistic infection agents [J] . Gangjee A, Jain HD, Queener SF, Journal of Medicinal Chemistry . 2008,第15期

机译：5-烷基修饰对吡咯并[2,3-d]嘧啶含有经典和非经典抗叶酸作为二氢叶酸还原酶抑制剂和抗肿瘤和/或抗机会感染剂的生物活性的影响
3. 2,4-Diamino-5-methyl-6-substituted arylthio-furo(2,3-d)pyrimidines as novel classical and nonclassical antifolates as potential dual thymidylate synthase and dihydrofolate reductase inhibitors. [J] . Gangjee A, Jain HD, Phan Bioorganic and medicinal chemistry . 2010,第2期

机译：2,4-二氨基-5-甲基-6-取代的芳硫基-呋喃（2,3-d）嘧啶类化合物是新型的经典和非经典抗叶酸药，它们是潜在的双重胸苷酸合酶和二氢叶酸还原酶抑制剂。
4. Probing drug mechanism of action via cellular metabolomics and fluxomics: An unexpected effect of the dihydrofolate reductase inhibitor trimethoprim [C] . Yun Kyung Kwon, Wenyun Lu, Joshua Rabinowitz ASMS Conference on Mass Spectrometry and Allied Topics . 2008

机译：细胞代谢组学探测作用的药物机制：二氢酚还原酶抑制剂的意外效果Trimethoprim
5. Design and synthesis of antifolates as inhibitors of dihydrofolate reductases in opportunistic pathogens (Pneumocystis carinii, Toxoplasma gondii). [D] . Li, Hui. 2000

机译：设计和合成作为机会病原体（卡氏肺孢子虫，弓形虫）中二氢叶酸还原酶抑制剂的抗叶酸剂。
6. The Effect of 5-Alkyl Modification on the Biological Activity of Pyrrolo23-dpyrimidine Containing Classical and Nonclassical Antifolates as Inhibitors of Dihydrofolate Reductase and as Antitumor and/or Antiopportunistic Infection Agents1a-e [O] . Aleem Gangjee, Hiteshkumar D. Jain, Sherry F. Queener, -1

机译：5-烷基修饰对含有经典和非经典抗叶酸作为二氢叶酸还原酶抑制剂和抗肿瘤和/或抗机会感染剂的吡咯并23-d嘧啶的生物活性的影响
7. Potent Dual Thymidylate Synthase and Dihydrofolate Reductase Inhibitors: Classical and Nonclassical 2-Amino-4-oxo-5-arylthio-substituted-6-methylthieno2,3-dpyrimidine Antifolates [O] . Aleem Gangjee, Yibin Qiu, Wei Li, 2008

机译：有效的双胸腺酯合酶和二氢氢醇还原酶抑制剂：经典和无菌2-氨基-4-氧代-5-芳硫基取代 - 6-甲基硫磺酸盐2,3-D嘧啶
8. Comparison of Dihydrofolate Reductases Obtained from Trimethoprim and Sulfonamide Resistance of (Neisseria gonorrhoeae). [R] . Ho, R. I., Corman, L. 1977

机译：甲氧苄氨嘧啶中二氢叶酸还原酶与（淋病奈瑟菌）抗磺胺类药物耐药性的比较。

Trimethoprim and other nonclassical antifolates an excellent template for searching modifications of dihydrofolate reductase enzyme inhibitors

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