• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>Journal of Clinical Medicine >Microscopic Peritoneal Residual Disease after Complete Macroscopic Cytoreductive Surgery for Advanced High Grade Serous Ovarian Cancer
【2h】

Microscopic Peritoneal Residual Disease after Complete Macroscopic Cytoreductive Surgery for Advanced High Grade Serous Ovarian Cancer

机译：微观腹膜残留疾病完全宏观细胞功能性手术治疗晚期高级血液癌症

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: Epithelial ovarian cancers (EOC) are usually diagnosed at an advanced stage and managed by complete macroscopic cytoreductive surgery (CRS) and systemic chemotherapy. Peritoneal recurrence occurs in 60% of patients and may be due to microscopic peritoneal metastases (mPM) which are neither eradicated by surgery nor controlled by systemic chemotherapy. The aim of this study was to assess and quantify the prevalence of residual mPM after complete macroscopic CRS in patients with advanced high-grade serous ovarian cancer (HGSOC). Methods: A prospective study conducted between 1 June 2018 and 10 July 2019 in a single referent center accredited by the European Society of Gynecological Oncology for advanced EOC management. Consecutive patients presenting with advanced HGSOC and eligible for complete macroscopic CRS were included. Up to 13 peritoneal biopsies were taken from macroscopically healthy peritoneum at the end of CRS and examined for the presence of mPM. A mathematical model was designed to determine the probability of presenting at least one mPM after CRS. Results: 26 patients were included and 26.9% presented mPM. There were no differences in characteristics between patients with or without identified mPM. After mathematical analysis, the probability that mPM remained after complete macroscopic CRS in patients with EOC was 98.14%. Conclusion: Microscopic PM is systematically present after complete macroscopic CRS for EOC and could be a relevant therapeutic target. Adjuvant locoregional strategies to conventional surgery may improve survival by achieving microscopic CRS.
机译：背景：上皮细胞卵巢癌（EOC）通常被诊断为晚期阶段，并通过完全宏观细胞功能性手术（CRS）和全身化疗进行管理。腹膜复发发生在60％的患者中，并且可能是由于显微腹膜转移（MPM），其既不被手术根源也没有通过全身化疗控制。本研究的目的是在高级高级浆液癌（HGSOC）患者中完全宏观CRS后评估和量化残留MPM的患病率。方法：2018年6月1日至2019年7月10日在欧洲妇科肿瘤学会高级EOC管理的一名指节中心进行了一项预期研究。包括患有先进的HGSOC并有资格获得完整宏观CRS的连续患者。在CRS结束时从宏观健康的腹膜中取出最多13个腹膜活组织检查，并检查MPM的存在。旨在确定在CRS之后呈现至少一个MPM的概率。结果：包括26名患者，呈现26.9％的MPM。有或没有鉴定的MPM的患者之间的特征没有差异。数学分析后，EOC患者完全宏观CRS后MPM保持概率为98.14％。结论：在完全宏观CRS的EOC后系统地存在显微镜PM，并且可以是相关的治疗目标。常规手术的佐剂型致策略可以通过实现微观CRS来改善存活。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号